Stress and the Gastrointestinal Tract -: III.: Stress-related alterations of gut motor function:: role of brain corticotropin-releasing factor receptors
Stress and the Gastrointestinal Tract -: III.: Stress-related alterations of gut motor function:: role of brain corticotropin-releasing factor receptors
复制标题
DOI：
10.1152/ajpgi.2001.280.2.g173
复制
发表时间：
2001-02-01
影响因子：
4.5
通讯作者：
Wang, LX
中科院分区：
文献类型：
--
作者：
Taché, Y;Martinez, V;Wang, LX
胃肠道（GI）运动功能的改变是内脏对应激反应的一部分。抑制胃排空和刺激结肠运动功能是各种应激源引起的常见模式。脑促肾上腺皮质激素释放因子（CRF）受体的激活通过与不同CRF受体亚型的相互作用介导上消化道的应激相关抑制和下消化道运动功能的刺激。CRF亚型1受体参与结肠和焦虑应激反应，可能与焦虑/抑郁和肠易激综合征的共病有临床相关性。
Alterations of gastrointestinal (GI) motor function are part of the visceral responses to stress. Inhibition of gastric emptying and stimulation of colonic motor function are the commonly encountered patterns induced by various stressors. Activation of brain corticotropin-releasing factor (CRF) receptors mediates stress-related inhibition of upper GI and stimulation of lower GI motor function through interaction with different CRF receptor subtypes. CRF subtype 1 receptors are involved in the colonic and anxiogenic responses to stress and may have clinical relevance in the comorbidity of anxiety/depression and irritable bowel syndrome.