Adult-born neurons are necessary for extended contextual discrimination
Adult-born neurons are necessary for extended contextual discrimination
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DOI：
10.1002/hipo.20895
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发表时间：
2012-02-01
期刊：
影响因子：
3.5
通讯作者：
Abrous, Djoher Nora
中科院分区：
文献类型：
--
作者：
Tronel, Sophie;Belnoue, Laure;Abrous, Djoher Nora
新的神经元在成年海马齿状回中不断产生。研究表明，成人神经发生的功能之一是支持空间模式分离，这是一个将相似记忆转化为非重叠表征的过程。这促使我们研究成年出生的神经元是否需要区分两种情况，即，识别熟悉的环境并检测其中引入的任何变化。我们表明，耗尽成年出生的神经元会削弱动物在广泛训练后消除两种背景的能力。这些数据表明，新的齿状神经元的连续生产在有效地提取和分离上下文表示，以区分事件内的功能中起着至关重要的作用。(C)2010 Wiley Periodicals，Inc.
New neurons are continuously produced in the adult dentate gyrus of the hippocampus. It has been shown that one of the functions of adult neurogenesis is to support spatial pattern separation, a process that transforms similar memories into nonoverlapping representations. This prompted us to investigate whether adult-born neurons are required for discriminating two contexts, i.e., for identifying a familiar environment and detect any changes introduced in it. We show that depleting adult-born neurons impairs the animal's ability to disambiguate two contexts after extensive training. These data suggest that the continuous production of new dentate neurons plays a crucial role in extracting and separating efficiently contextual representation in order to discriminate features within events. (C) 2010 Wiley Periodicals, Inc.