Neglected tropical disease vaccines
Neglected tropical disease vaccines
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DOI：
10.1016/j.biologicals.2009.02.008
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发表时间：
2009-06-01
期刊：
影响因子：
1.7
通讯作者：
Brown, Ami Shah
中科院分区：
文献类型：
--
作者：
Hotez, Peter J.;Brown, Ami Shah
被忽视的热带病或“NTD”是世界上 10 亿最贫困人口最常见的感染性疾病。与广为人知的急性或新发感染不同，NTD 通常是慢性且致残（且常常毁容）的疾病。它们造成的长期残疾已被揭示为发展中国家贫困人口无法摆脱贫困陷阱的主要原因。由于被忽视的热带病与贫困有关，因此针对这些疾病的疫苗有时被称为抗贫困疫苗。然而，尽管此类疫苗对全球公共卫生和经济具有重要意义，但它们在很大程度上被业界忽视，目前主要通过非营利产品开发伙伴关系 (PDP) 的活动生产。萨宾疫苗研究所的人类钩虫疫苗计划就是此类 PDP 之一，该项目分别针对钩虫和血吸虫病开发两种抗贫困疫苗。有人建议将这些疫苗结合起来，以针对导致严重贫血的多寄生虫合并感染。最终，为了确保全球获得多价驱虫疫苗，它可能会通过疫苗相关化疗与驱虫计划联系起来。这将是到 2015 年实现可持续减贫千年发展目标的重要一步。(C) 2009 国际生物制品协会。由爱思唯尔有限公司出版。保留所有权利。
The neglected tropical diseases or 'NTDs' represent the most common infections of the world's one billion poorest people. Unlike the better known acute or emerging infections, the NTDs are generally chronic and disabling (and often disfiguring) conditions. The long-term disability they cause has been revealed as a major reason why poor people in developing countries cannot escape the poverty trap. Because NTDs are associated with poverty, vaccines against these conditions are sometimes referred to as antipoverty vaccines. However, despite their global public health and economic importance, such vaccines have largely been ignored by industry and today are predominantly being produced through the activities of non-profit product development partnerships (PDPs). The Human Hookworm Vaccine Initiative based at the Sabin Vaccine Institute is one such PDP developing two antipoverty vaccines for hookworm and schistosomiasis, respectively. It has been proposed to combine these vaccines in order to target polyparasitic co-infections leading to severe anemia. Ultimately, to ensure global access of a multivalent anthelminthic vaccine, it may be linked to deworming programs through vaccine-linked chemotherapy. This would be an important step towards achieving the Millennium Development Goals for sustainable poverty reduction by 2015. (C) 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.