Effects of nicotine and stress on startle amplitude and sensory gating depend on rat strain and sex
Effects of nicotine and stress on startle amplitude and sensory gating depend on rat strain and sex
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DOI：
10.1016/s0091-3057(98)00159-2
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发表时间：
1999-02-01
影响因子：
3.6
通讯作者：
Grunberg, NE
中科院分区：
文献类型：
--
作者：
Faraday, MM;O'Donoghue, VA;Grunberg, NE
我们最近报道，给予雄性和雌性 Long-Evans 大鼠 14 天的尼古丁（12 毫克/公斤/天）会降低声惊跳反射幅度，并损害惊跳前脉冲抑制 (PPI) (24)。这些发现与尼古丁诱导 Sprague-Dawley（另一种品系）雄性大鼠惊吓和 PPI 增强的报道形成鲜明对比 (24)。本实验通过渗透微型泵向 120 只 Sprague-Dawley 大鼠（雄性和雌性）和 120 只 Long-Evans 大鼠（雄性和雌性）施用 0、6 或 12 mg/kg/天的尼古丁 14 天，并检查 ASR 和 PPI。一半的受试者还因每天一次固定而感到压力，以检查尼古丁与压力的相互作用。尼古丁增强了 Sprague-Dawley 大鼠的 ASR 和 PPI 反应，但损害了 Long-Evans 大鼠的这些反应，无论性别如何。压力的影响很复杂，取决于压力、性别和药物剂量。这些发现表明，尼古丁对反应性 (ASR) 和感觉门控 (PPI) 测量的影响取决于基因型，而尼古丁与应激的相互作用取决于基因型、性别和尼古丁剂量。 (C) 1999 爱思唯尔科学公司。
We recently reported that 14 days of nicotine administration (12 mg/kg/day) reduced acoustic startle reflex amplitude and impaired prepulse inhibition (PPI) of startle in male and female Long-Evans rats (24). These findings contrasted with reports of nicotine-induced enhancement of startle and PPI in Sprague-Dawley (a different strain) male rats (24). The present experiment administered 0, 6, or 12 mg/kg/day nicotine via osmotic minipump for 14 days to 120 Sprague-Dawley rats (male and female) and to 120 Long-Evans rats (male and female) and examined ASR and PPI. Half of the subjects also were stressed by immobilization once each day to examine nicotine-stress interactions. Nicotine enhanced ASR and PPI responses of Sprague-Dawley rats but impaired these responses in Long-Evans rats, regardless of sex. Effects of stress were complex and depended on strain, sex, and drug dose. These findings indicate that effects of nicotine on measures of reactivity (ASR) and sensory gating (PPI) depend on genotype and that nicotine-stress interactions depend on genotype, sex, and nicotine dosage. (C) 1999 Elsevier Science Inc.