SUPPRESSION OF IGE RESPONSES FOLLOWING INHALATION OF ANTIGEN - A NATURAL HOMEOSTATIC MECHANISM WHICH LIMITS SENSITIZATION TO AEROALLERGENS
SUPPRESSION OF IGE RESPONSES FOLLOWING INHALATION OF ANTIGEN - A NATURAL HOMEOSTATIC MECHANISM WHICH LIMITS SENSITIZATION TO AEROALLERGENS
复制标题
DOI：
10.1016/0167-5699(87)90825-5
复制
发表时间：
1987-01-01
期刊：
影响因子：
--
通讯作者：
SEDGWICK, JD
中科院分区：
文献类型：
--
作者：
HOLT, PG;SEDGWICK, JD
免疫细胞与空气中抗原的接触在上呼吸道（URT）受到粘液等物理屏障的限制。但有些抗原确实能穿透上呼吸道上皮。在这篇文章中，Patrick Holt和Jon Sedgwick假设存在备用免疫机制，可以防止对跨越上皮屏障的抗原致敏。上呼吸道（URT）粘膜实际上经常接触来自自然环境的空气传播的抗原物质，其中绝大多数是非致病性的。一系列有效的重叠排斥屏障，包括鼻腔内的粗过滤，上皮细胞之间的紧密连接，以及与分泌抗体协同工作的黏毛运输系统1，共同限制了局部免疫细胞群与传入抗原之间的有效接触。
Contact between immune cells and airborne antigens is limited in the upper respiratory tract (URT) by physical barriers such as mucous. But some antigen does penetrate the URT epithefium. In this article, Patrick Holt and Jon Sedgwick postulate the existence of back-up immune mechanisms which prevent sensitization to antigens which cross epithelial barriers.The mucosa of the upper respiratory tract (URT) is in virtually constant contact with airborne antigenic material from the natural environment, the vast majority of which is non-pathogenic. An efficient series of overlapping exclusion barriers, which include crude filtration in the nares, tight junctions between epithelial cells, and the mucociliary transport system functioning in concert with secretory antibodies 1, collectively limit effective contact between local immune cell populations and incoming antigen.