Langerhans' cell and vitiligo: quantitative study of T6 and HLA-DR antigen-expressing cells.
Langerhans' cell and vitiligo: quantitative study of T6 and HLA-DR antigen-expressing cells.
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朗格汉斯细胞和白癜风：T6 和 HLA-DR 抗原表达细胞的定量研究。
DOI：
10.1056/nejm198007103030220
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发表时间：
1984
影响因子：
3.6
通讯作者：
B. Rouchouse
中科院分区：
文献类型：
--
作者：
A. Claudy;B. Rouchouse
对10例普通白癜风患者白癜风皮肤（VS）和正常皮肤（NAS）表皮朗格汉斯细胞（LC）密度进行了研究。单克隆小鼠抗人T6抗原IgG1和Ia抗原IgG2 （Ortho Pharmaceuticals）用于LC的表征。表皮LC密度通过眼方网格计算，每0.1 mm2表示。结果表明，VS的LC密度与NAS相似（p：无统计学意义）。在年龄，性别，进展，稳定或重新着色白癜风方面没有差异。我们的结论是，LC参与白癜风，如果有的话，不可能发生通过退化机制，或通过区域密度的变化。
Epidermal Langerhans' cell (LC) densities in vitiliginous skin (VS) and normal-appearing skin (NAS) were studied in 10 patients with common vitiligo. Monoclonal mouse anti human T6 antigen IgG1 and Ia antigen IgG2 (Ortho Pharmaceuticals) were used to characterize LC. Epidermal LC densities were calculated by means of an ocular square grid and expressed per 0.1 mm2. The results showed that LC densities of VS was similar to that of NAS (p: not significant). No differences were noted in terms of age, sex, progressing, stable or repigmenting vitiligo. We concluded that involvement of LC in vitiligo, if any, does not probably occur via a degenerating mechanism, or via variations in regional densities.