Reducèd in vitro response to concanavalin A and lipopolysaccharide in senescent mice: a function of reduced number of responding cells
Reducèd in vitro response to concanavalin A and lipopolysaccharide in senescent mice: a function of reduced number of responding cells
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衰老小鼠对刀豆球蛋白 A 和脂多糖的体外反应减少：反应细胞数量减少的作用
DOI：
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发表时间：
1977
影响因子：
5.4
通讯作者：
H. Gershon
中科院分区：
文献类型：
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作者：
C. Abraham;Y. Tal;H. Gershon
对12月龄和28月龄小鼠对Con A和LPS反应的细胞周期的研究表明，单个增殖细胞的生成时间不随年龄而改变。对LPS产生反应的B细胞和对Con a产生反应的T细胞也没有什么不同。这些研究还表明，衰老小鼠的增殖细胞与1岁成年小鼠的细胞一样具有重复细胞分裂的能力。由此得出结论，衰老小鼠对多克隆有丝分裂原LPS和Con a的体外反应减少的缺陷是反应细胞数量的减少，而不是那些对分裂有反应的细胞能力的改变。
Studies of the cell cycle of cells responding to Con A and to LPS from 12 and 28‐month‐old mice demonstrate that the generation time of individual proliferating cells does not alter with age. Nor does it differ for the B cells responding to LPS or the T cells responding to Con A. These studies also demonstrate that the proliferating cells from senescent mice are equally capable of repeated cell divisions as are the cells from the 1‐year‐old adult mouse. It is concluded that the defect in senescent mice which leads to a reduced in vitro response to the polyclonal mitogens LPS and Con A is a reduction in the number of responding cells and not an alteration in the capacity of those cells which do respond to divide.