The cereal pathogen Fusarium pseudograminearum produces a new class of active cytokinins during infection.
The cereal pathogen Fusarium pseudograminearum produces a new class of active cytokinins during infection.
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DOI：
10.1111/mpp.12593
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发表时间：
2018-05
影响因子：
4.9
通讯作者：
J. L. Sørensen;A. Benfield;R. Wollenberg;K. Westphal;R. Wimmer;M. R. Nielsen;K. Nielsen;J. Carere;L. Covarelli;G. Beccari;J. Powell;T. Yamashino;H. Kogler;T. E. Sondergaard;D. Gardiner
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文献类型：
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作者：
J. L. Sørensen;A. Benfield;R. Wollenberg;K. Westphal;R. Wimmer;M. R. Nielsen;K. Nielsen;J. Carere;L. Covarelli;G. Beccari;J. Powell;T. Yamashino;H. Kogler;T. E. Sondergaard;D. Gardiner
真菌病原体假禾谷镰刀菌（Fusarium pseudograminearum）引起小麦和大麦的重要病害。在调查该真菌产生的次级代谢产物期间，发现了一类新的细胞分裂素，本文称为镰孢细胞分裂素。已知细胞分裂素具有促进生长和抗衰老的活性，并且曾经被认为是促进细胞死亡和衰老的坏死营养型病原体的细胞分裂素模拟物的产生挑战了这种病原体通过采用大量溶解酶和毒素入侵其宿主的简单观点。通过基因组挖掘，在F。鉴定了产生镰刀菌细胞分裂素的pseudograminearum基因组，并使用基因敲除建立了生物合成途径。镰刀菌细胞分裂素可以激活植物细胞分裂素信号，证明了它们真正的激素模拟。在植物中的转录响应镰刀菌细胞分裂素的分析表明，这些分子的宿主环境的广泛重编程，可能通过与防御激素信号通路的串扰。
The fungal pathogen Fusarium pseudograminearum causes important diseases of wheat and barley. During a survey of secondary metabolites produced by this fungus, a novel class of cytokinins, herein termed Fusarium cytokinins, was discovered. Cytokinins are known for their growth-promoting and anti-senescence activities, and the production of a cytokinin mimic by what was once considered as a necrotrophic pathogen that promotes cell death and senescence challenges the simple view that this pathogen invades its hosts by employing a barrage of lytic enzymes and toxins. Through genome mining, a gene cluster in the F. pseudograminearum genome for the production of Fusarium cytokinins was identified and the biosynthetic pathway was established using gene knockouts. The Fusarium cytokinins could activate plant cytokinin signalling, demonstrating their genuine hormone mimicry. In planta analysis of the transcriptional response to one Fusarium cytokinin suggests extensive reprogramming of the host environment by these molecules, possibly through crosstalk with defence hormone signalling pathways.