The role of HOX genes in human implantation
The role of HOX genes in human implantation
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DOI：
10.1196/annals.1335.001
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Taylor, HS
中科院分区：
文献类型：
--
作者：
Kwon, HE;Taylor, HS
子宫内膜经历有序的分化过程，导致胚胎着床的接受性。HOX基因以类似于它们指导胚胎发育的方式指导这种发育，包括生殖道的发育。HOXA 10和HOXA 11的表达在月经周期中增加，在着床时的黄体中期急剧增加。这种表达受性类固醇激素调节。这种表达是胚泡着床所必需的，如HOX表达改变的女性中着床率降低所证明的。HOX基因是子宫内膜容受性的标志。通过基因治疗增强HOX基因表达以改善植入的可能性在未来有希望。
The endometrium undergoes an ordered process of differentiation leading to receptivity to embryonic implantation. HOX genes direct this development in a fashion similar to that in which they direct embryonic development, including development of the reproductive tract. HOXA10 and HOXA11 expression increases during the menstrual cycle, increasing drastically in the midluteal phase, at the time of implantation. This expression is regulated by sex steroid hormones. This expression is necessary for implantation of the blastocyst as demonstrated by the decreased implantation rates in women with altered HOX expression. HOX genes are markers of endometrial receptivity. The possibility of augmenting HOX gene expression with gene therapy to improve implantation has promise for the future.