Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon
Overexpression of a novel superoxide-producing enzyme, NADPH oxidase 1, in adenoma and well differentiated adenocarcinoma of the human colon
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DOI：
10.1016/j.canlet.2004.08.031
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发表时间：
2005-04-18
期刊：
影响因子：
9.7
通讯作者：
Tashiro, S
中科院分区：
文献类型：
--
作者：
Fukuyama, M;Rokutan, K;Tashiro, S
超氧化物生成酶NADPH氧化酶1（Nox 1）主要在结肠中表达，与结肠癌的发病机制有关。免疫组化结果显示，Nox 1主要表达于粘膜上皮细胞。腺瘤和高分化腺癌上调Nox 1表达。Ki-67阴性、分化良好的肿瘤细胞中含有丰富的Nox 1，而Ki-67阳性、增殖细胞中不表达Nox 1，这种在正常和肿瘤组织中的分化依赖性表达表明Nox 1除了促有丝分裂功能外还具有不同的作用。核因子（NF）-κ B主要在表达丰富的Nox 1的腺瘤和腺癌细胞中被激活，这表明Nox 1可能刺激结肠肿瘤中NF-κ B依赖的抗凋亡途径。(c)2004爱思唯尔爱尔兰有限公司保留所有权利。
A superoxide-producing enzyme, NADPH oxidase 1 (Nox1), dominantly expressed in the colon, is implicated in the pathogenesis of colon cancer. Immunohistochemistry showed that Nox1 was constitutively expressed in surface mucous cells. Adenomas and well differentiated adenocarcinomas up-regulated Nox1 expression. Ki-67-negative, well differentiated tumor cells contained abundant Nox1, whereas Ki-67-positive, proliferating cells did not express it. This differentiation-dependent expression in normal as well as tumor tissues suggests distinct roles of Nox1 besides mitogenic function. Nuclear factor (NF)-kappa B was predominantly activated in adenoma and adenocarcinoma cells expressing abundant Nox1, suggesting that Nox1 may stimulate NF-kappa B-dependent antiapoptotic pathways in colon tumors. (c) 2004 Elsevier Ireland Ltd. All rights reserved.