Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma.
Identification of the prognostic value of lymphocyte-to-monocyte ratio in patients with HBV-associated advanced hepatocellular carcinoma.
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淋巴细胞与单核细胞比值对 HBV 相关晚期肝细胞癌患者预后价值的鉴定
DOI：
10.3892/ol.2017.6420
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发表时间：
2017-08
期刊：
影响因子：
2.9
通讯作者：
Wu XY
中科院分区：
文献类型：
--
作者：
Hong YF;Chen ZH;Wei L;Ma XK;Li X;Wen JY;Wang TT;Cai XR;Wu DH;Chen J;Ruan DY;Lin ZX;Lin Q;Dong M;Wu XY
炎症微环境在肝细胞癌（HCC）的进展中起重要作用。外周血淋巴细胞与单核细胞比率（LMR）作为一种新的炎症生物标志物，结合了宿主免疫稳态与肿瘤微环境的估计，已被确定为许多恶性肿瘤临床结局的预测因子。本研究旨在探讨LMR在与B型肝炎病毒（HBV）相关的晚期肝癌患者中的预后价值。共分析了174例HBV相关晚期HCC患者，无发热或感染体征。临床病理学参数，包括LMR，进行了评估，以确定总生存时间的预测因子。采用考克斯比例风险模型进行单变量和多变量分析。使用时间依赖性受试者工作特征曲线确定阈值。单因素和多因素分析显示，LMR是HBV相关晚期HCC患者总生存时间的独立预后因素（P<0.05）。LMR的阈值为2.22。所有患者分为低LMR组（≤2.22）和高LMR组（>2.22）。高LMR组的OS时间明显长于低LMR组（P<0.001）。高LMR组患者3个月和6个月OS率显著高于低LMR组患者（P<0.001）。LMR水平的升高与转移、腹水和肿瘤体积的增大显著相关（P<0.01）。LMR是HBV相关晚期HCC患者的独立预后因素，基线LMR水平升高提示预后改善。
The inflammatory microenvironment serves an important function in the progression of hepatocellular carcinoma (HCC). Peripheral blood lymphocyte-to-monocyte ratio (LMR), as a novel inflammatory biomarker combining an estimate of host immune homeostasis with the tumor microenvironment, has been identified to be a predictor of clinical outcomes in a number of malignancies. The present study aimed at investigating the prognostic value of LMR in patients with hepatitis B virus (HBV)-associated advanced HCC. A total of 174 patients with HBV-associated advanced HCC, without fever or signs of infections, were analyzed. Clinicopathological parameters, including LMR, were evaluated to identify predictors of overall survival time. Univariate and multivariate analysis was performed using Cox's proportional hazards model. A threshold value was determined using a time-dependent receiver operating characteristic curve. Univariate and multivariate analysis identified LMR as an independent prognostic factor in overall survival (OS) time in patients with HBV-associated advanced HCC (P<0.05). The threshold value of LMR was 2.22. All patients were divided into either a low LMR group (≤2.22) or a high LMR group (>2.22). The OS time of the high LMR group was significantly longer compared with the low LMR group (P<0.001). Patients in the high LMR group exhibited a significantly increased 3-month and 6-month OS rate, compared with that of the patients within the low LMR group (P<0.001). An increased level of LMR was significantly associated with the presence of metastasis, ascites and increased tumor size (P<0.01). LMR is an independent prognostic factor of HBV-associated advanced HCC patients and an increased baseline LMR level indicates an improved prognosis.
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影响因子：
--
作者：
Grosse-Steffen T;Giese T;Giese N;Longerich T;Schirmacher P;Hänsch GM;Gaida MM
通讯作者：
Gaida MM
影响因子：
7.4
作者：
Deng Q;He B;Liu X;Yue J;Ying H;Pan Y;Sun H;Chen J;Wang F;Gao T;Zhang L;Wang S
通讯作者：
Wang S
影响因子：
3.7
作者：
Chen YM;Lai CH;Chang HC;Chao TY;Tseng CC;Fang WF;Wang CC;Chung YH;Wang YH;Su MC;Huang KT;Chen HC;Chang YC;Lin MC
通讯作者：
Lin MC
影响因子：
13.5
作者：
Aleksandrova, Krasimira;Boeing, Heiner;Noethlings, Ute;Jenab, Mazda;Fedirko, Veronika;Kaaks, Rudolf;Lukanova, Annekatrin;Trichopoulou, Antonia;Trichopoulos, Dimitrios;Boffetta, Paolo;Trepo, Elisabeth;Westhpal, Sabine;Duarte-Salles, Talita;Stepien, Magdalena;Overvad, Kim;Tjonneland, Anne;Halkjaer, Jytte;Boutron-Ruault, Marie-Christine;Dossus, Laure;Racine, Antoine;Lagiou, Pagona;Bamia, Christina;Benetou, Vassiliki;Agnoli, Claudia;Palli, Domenico;Panico, Salvatore;Tumino, Rosario;Vineis, Paolo;Bueno-De-Mesquita, Bas;Peeters, Petra H.;Gram, Inger Torhild;Lund, Eiliv;Weiderpass, Elisabete;Quiros, J. Ramon;Agudo, Antonio;Sanchez, Maria-Jose;Gavrila, Diana;Barricarte, Aurelio;Dorronsoro, Miren;Ohlsson, Bodil;Lindkvist, Bjoern;Johansson, Anders;Sund, Malin;Khaw, Kay-Tee;Wareham, Nicholas;Travis, Ruth C.;Riboli, Elio;Pischon, Tobias
通讯作者：
Pischon, Tobias
五种终末期肝病模型预测晚期肝细胞癌患者生存率的比较
影响因子：
--
作者：
Hong, Ying-Fen;Chen, Zhan-Hong;Wu, Xiang-Yuan
通讯作者：
Wu, Xiang-Yuan