(+/-)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats.
(+/-)3,4-Methylenedioxymethamphetamine (MDMA) produces long-term reductions in brain 5-hydroxytryptamine in rats.
复制标题
( /-)3,4-亚甲二氧基甲基苯丙胺 (MDMA) 会长期降低大鼠脑中 5-羟色胺的含量。
DOI：
10.1016/0014-2999(87)90441-9
复制
发表时间：
1987
影响因子：
5
通讯作者：
Rosecrans,JA
中科院分区：
文献类型：
--
作者：
Mokler,DJ;Robinson,SE;Rosecrans,JA
大鼠皮下注射(±)3，4-亚甲基二氧基甲基苯丙胺(MDMA)40 mg/kg。或40 mg/kg皮下注射。每隔一天注射4次。最后一次注射后16天，大鼠被处死。MDMA引起海马区和额叶皮质5-羟色胺及其代谢物5-HIAA的显著减少。单次给药后，5-羟色胺在海马区的含量降至对照组的30%。下丘脑的5-羟色胺水平没有受到影响，这表明对大脑5-羟色胺系统有不同的影响。4次给药后，大鼠下丘脑DA水平明显升高，额叶皮质NE水平下降至对照组的73%。因此，MDMA会导致5-羟色胺的长期枯竭，这表明它可能作为一种神经毒素作用于大鼠大脑中的5-羟色胺神经元。
(±)3,4-Methylenedioxymethamphetamine (MDMA) was administered to rats as a single 40 mg/kg injection s.c. or 40 mg/kg s.c. every second day for 4 injections. Sixteen days following the last injection rats were killed. MDMA produced significant depletions of 5-HT and its metabolite 5-HIAA in the hippocampus and the frontal cortex. 5-HT was depleted to 30% of control value in the hippocampus following a single dose. 5-HT levels were not affected in the hypothalamus, suggesting differential effects on brain 5-HT systems. DA levels in the hypothalamus were significantly increased while NE levels in the frontal cortex were decreased to 73% of control following 4 doses of MDMA. MDMA, therefore, produces long-term depletions in 5-HT which suggests that it may act as a neurotoxin at 5-HT neurons in the brain of rats.