Role of complement in porphyrin-induced photosensitivity.
Role of complement in porphyrin-induced photosensitivity.
复制标题
补体在卟啉诱导的光敏性中的作用。
DOI：
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发表时间：
1981
影响因子：
6.5
通讯作者：
Irma Gigli
中科院分区：
文献类型：
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作者：
H. Lim;Irma Gigli
在体外豚鼠血清中添加卟啉，并在405 nm光照射下，对补体（CH50， C3和C5）的溶血活性产生剂量依赖性抑制。以豚鼠为动物模型，我们还发现，在405nm光照射下，系统给药卟啉对体内CH50有剂量依赖性的抑制作用。卟啉处理的豚鼠红细胞对405 nm辐照诱导溶血的敏感性增加。这些动物的临床变化仅限于光照区域，包括红斑、结痂和毛发生长延迟。组织学上观察到真皮水肿、血管扩张、单核和多形核细胞浸润。经紫外线b照射的豚鼠出现红斑，但补体谱未发生改变。这表明补体产品可能在某些卟啉症皮肤病变的发病机制中起特定的作用。
Addition of porphyrins to sera of guinea pigs in vitro, followed by irradiation with 405 nm light, resulted in dose-dependent inhibitions of hemolytic activity of complement (CH50, C3, and C5). With guinea pig as an animal model, we also found that systemically administered porphyrins, followed by irradiation with 405 nm light, resulted in dose-dependent inhibition of CH50 in vivo. The erythrocytes from porphyrin-treated guinea pigs showed an increased susceptibility to hemolysis induced by 405 nm irradiation in vitro. Clinical changes in these animals were limited to light-exposed areas and consisted of erythema, crusting, and delayed growth of hair. Histologically, dermal edema, dilation of blood vessels, and infiltration of mononuclear and polymorphonuclear cells were observed. Guinea pigs irradiated with ultraviolet-B developed erythema, but had no alteration of their complement profiles. It is suggested that complement products may play a specific role in the pathogenesis of the cutaneous lesions of some porphyrias.