Diffusion-weighted magnetic resonance imaging of white matter in bipolar disorder: a pilot study
Diffusion-weighted magnetic resonance imaging of white matter in bipolar disorder: a pilot study
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DOI：
10.1111/j.1399-5618.2006.00281.x
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发表时间：
2006-04-01
影响因子：
5.4
通讯作者：
Gullapalli, RP
中科院分区：
文献类型：
--
作者：
Regenold, WT;D'Agostino, CA;Gullapalli, RP
目的：与传统的t2加权MRI相比，弥散加权磁共振成像（MRI）在检测脑白质疾病方面显示出更高的灵敏度。扩散加权成像（DWI）可以利用平均表观扩散系数（ADC(av)）定量评估白质的微观结构完整性，ADC（av）是衡量水分子在组织内自由移动程度的指标。在大量研究表明双相情感障碍患者存在白质疾病，特别是病情较重的患者的基础上，本研究旨在测试DWI在评估重症双相情感障碍患者白质完整性方面的实用性。方法：回顾性分析8例双相情感障碍患者和8例年龄匹配的神经系统疾病对照者的MRI扫描结果。计算感兴趣的白质区域（ROI）内像素的ADC（av）值，并用于绘制每个ROI的ADC（av）频率直方图。然后用ANCOVA比较两组的平均ADC（av）值。结果：双极平均ADC(av) (0.855 +/- 0.051 × 10（-3) mm(2)/s）显著高于对照组(0.799 +/- 0.046 × 10(-3) mm(2)/s)，与年龄相关（F = 4.47, df = 3, p = 0.025）。结论：这是双相情感障碍患者白质ADC（av）升高的首次报道。在这组重症患者中，白质ADC（av）升高表明微结构改变与白质完整性下降一致。DWI可能是评估双相情感障碍患者白质异常的另一种有用工具。
Objective: Diffusion-weighted magnetic resonance imaging (MRI) has shown increased sensitivity in detecting brain white matter disease compared to traditional T2-weighted MRI. Diffusion-weighted imaging (DWI) can quantitatively assess the microstructural integrity of white matter using the average apparent diffusion coefficient (ADC(av)), a measure of the extent to which water molecules move freely within tissue. On the basis of numerous studies suggesting white matter disease in bipolar patients, particularly patients with more severe illness, this study aimed to test the utility of DWI in assessing the white matter integrity of bipolar patients with severe illness.Methods: The existing MRI scans of eight bipolar patients and eight age-matched controls with neurological illness were examined retrospectively. ADC(av) values for pixels within white matter regions of interest (ROIs) were calculated and used to plot ADC(av) frequency histograms for each ROI. Mean ADC(av) values for the two groups were then compared by ANCOVA.Results: The bipolar mean ADC(av) (0.855 +/- 0.051 x 10(-3) mm(2)/s) for combined white matter ROIs significantly exceeded that of controls (0.799 +/- 0.046 x 10(-3) mm(2)/s), while covarying for age (F = 4.47, df = 3, p = 0.025).Conclusions: This is the first report of an elevated ADC(av) in the white matter of a group of patients with bipolar disorder. In this group of patients with severe illness, increased white matter ADC(av) suggests microstructural changes consistent with decreased white matter integrity. DWI may be an additional, useful tool to assess white matter abnormalities in bipolar disorder.