Photoinduced NO-release from polymer dots doped with an Ir(<scp>iii</scp>) complex and <i>N</i>-methyl-<i>N</i>-nitroso-4-aminophenol
Photoinduced NO-release from polymer dots doped with an Ir(<scp>iii</scp>) complex and <i>N</i>-methyl-<i>N</i>-nitroso-4-aminophenol
复制标题
掺杂 Ir(<scp>iii</scp>) 络合物和 <i>N</i>-甲基-<i>N</i>-亚硝基-4-氨基苯酚的聚合物点光诱导 NO 释放
DOI：
10.1039/d3ob00047h
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Nakagawa Hidehiko
中科院分区：
文献类型：
--
作者：
Saitoh Daisuke;Suzuki Ayumi;Ieda Naoya;Liu Zuoyue;Osakada Yasuko;Fujitsuka Mamoru;Kawaguchi Mitsuyasu;Nakagawa Hidehiko
一氧化氮（NO）是一种信号分子，在人体内发挥多种功能，但由于其在生物环境中的高反应性和不稳定性，很难将其用于生物实验或治疗目的。因此，光控NO释放，使时空控制NO释放，有一个重要的作用，在阐明NO的功能。我们的小组已经开发了可见光可控的NO释放分子，含有荧光染料结构作为光捕获天线部分和N-亚硝基氨基苯酚结构作为NO释放部分。在这里，我们的目标是构建一个NO生成系统，采用分子间的光氧化还原反应之间的两个单独的组件，因为这将简化化学合成，使其更容易检查各种染料作为天线。为此，我们构建了掺杂有N-甲基-N-亚硝基-4-氨基苯酚（NAP，1）和Ir（III）天线络合物（2、3或4）的聚合物纳米颗粒，以便在没有共溶剂的情况下溶解在水溶液中。这些聚合物纳米颗粒在体外紫（400-430 nm）或蓝（400-460 nm）波长区域的光照射下释放NO以激活掺杂的Ir（III）络合物。
Nitric oxide (NO) is a signaling molecule that plays a variety of functions in the human body, but it is difficult to use it in biological experiments or for therapeutic purposes because of its high reactivity and instability in the biological milieu. Consequently, photocontrollable NO releasers, which enable spatiotemporal control of NO release, have an important role in elucidating the functions of NO. Our group has developed visible-light-controllable NO-releasing molecules that contain a fluorescent dye structure as a light-harvesting antenna moiety and an N-nitrosoaminophenol structure as an NO-releasing moiety. Here, we aimed to construct an NO-generating system employing an intermolecular photoredox reaction between the two separate components, since this would simplify chemical synthesis and make it easier to examine various dyes as antennae. For this purpose, we constructed polymer nanoparticles doped with both N-methyl-N-nitroso-4-aminophenol (NAP, 1) and an Ir(III) antenna complex (2, 3 or 4) in order to dissolve in aqueous solution without a co-solvent. These polymer nanoparticles released NO upon photoirradiation in vitro in the purple (400–430 nm) or blue (400–460 nm) wavelength region to activate the doped Ir(III) complex.