Role of quantitative hepatitis B core antibody levels in predicting significant liver inflammation in chronic hepatitis B patients with normal or near-normal alanine aminotransferase levels
Role of quantitative hepatitis B core antibody levels in predicting significant liver inflammation in chronic hepatitis B patients with normal or near-normal alanine aminotransferase levels
复制标题
定量乙型肝炎核心抗体水平在预测丙氨酸转氨酶水平正常或接近正常的慢性乙型肝炎患者显着肝脏炎症中的作用
DOI：
10.1111/hepr.12937
复制
发表时间：
2018-02-01
影响因子：
4.2
通讯作者：
Xia, Ning-Shao
中科院分区：
文献类型：
--
作者：
Li, Jing;Zhang, Tian-Ying;Xia, Ning-Shao
目的：丙氨酸氨基转移酶（ALT）水平正常的慢性B型肝炎（CH B）患者并非没有明显的肝脏病变。最近，对CH B管理期间定量B核心抗体水平（qAnti-HBc）的临床意义有了更好的理解。在这项横断面研究中，我们评估了qAnti-HBc在识别CHB patients.Methods显著肝脏炎症中的效用：共纳入469例接受肝活检（LB）的患者（训练集，n=363;验证集，n=106）。结果：在训练集中，qAnti-HBc水平对所有患者的中重度肝脏炎症（≥ G2）具有显著的诊断价值（受试者工作特征曲线下面积[AUROC]=0.768; 95%可信区间[CI]，0.721-0.810; P
Aim: Chronic hepatitis B (CHB) patients with normal alanine aminotransferase (ALT) levels are not free from significant hepatic lesions. Recently, there has been an improved understanding of the clinical significance of quantitative hepatitis B core antibody levels (qAnti-HBc) during CHB management. In this cross-sectional study, we evaluated the utility of qAnti-HBc in identifying significant liver inflammation in CHB patients.Methods: A total of 469 patients (training set, n=363; validation set, n=106) who underwent liver biopsy (LB) were included. The qAnti-HBc levels were quantified and the relationship between histology and serum markers was systematically analyzed.Results: In the training set, qAnti-HBc levels were found to have significant diagnostic value for moderate to severe liver inflammation (>= G2) in all patients (area under the receiver operating characteristic curve [AUROC]=0.768; 95% confidence interval [CI], 0.721-0.810; P