Importance of dietary γ-linolenic acid in human health and nutrition?
Importance of dietary γ-linolenic acid in human health and nutrition?
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DOI：
10.1093/jn/128.9.1411
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发表时间：
1998-09-01
影响因子：
4.2
通讯作者：
Chapkin, RS
中科院分区：
文献类型：
--
作者：
Fan, YY;Chapkin, RS
关于单个多不饱和脂肪酸（PUFA）的独特生物活性仍然存在相当大的争论。最有趣但有争议的饮食方法之一是饮食γ-亚麻酸（GLA）在治疗各种慢性疾病状态中可能的预防作用。这种策略是基于饮食改变细胞脂质组成和类花生酸（环氧合酶和脂氧合酶）生物合成的能力。最近的研究表明，膳食GLA增加其延伸酶产物，二高-γ-亚麻酸（DGLA），在细胞膜内的含量，而不伴随花生四烯酸（AA）的变化。随后，在刺激后，DGLA可以被炎症细胞转化为15-（S）-羟基-8，11，13-二十碳三烯酸和前列腺素E-1。这是值得注意的，因为这些化合物具有抗炎和抗增殖特性。虽然一个最佳的喂养方案，以最大限度地提高饮食GLA的潜在利益尚未确定，这是本综述的目的，总结最近的研究，重点是客观和可重复地确定GLA可能改善健康问题的机制（S）。
Considerable debate remains regarding the distinct biological activities of individual polyunsaturated fatty acids (PUFA). One of the most interesting yet controversial dietary approaches has been the possible prophylactic role of dietary gamma-linolenic acid (GLA) in treating various chronic disease states. This strategy is based on the ability of diet to modify cellular lipid composition and eicosanoid (cyclooxygenase and lipoxygenase) biosynthesis. Recent studies demonstrate that dietary GLA increases the content of its elongase product, dihomo-gamma-linolenic acid (DGLA), within cell membranes without concomitant changes in arachidonic acid (AA). Subsequently, upon stimulation, DGLA can be converted by inflammatory cells to 15-(S)-hydroxy-8,11,13-eicosatrienoic acid and prostaglandin E-1. This is noteworthy because these compounds possess both anti-inflammatory and anti-protiferative properties. Although an optimal feeding regimen to maximize the potential benefits of dietary GLA has not yet been determined, it is the purpose of this review to summarize the most recent research that has focused on objectively and reproducibly determining the mechanism(s) by which GLA may ameliorate health problems.