Conditioned overconsumption is dependent on reinforcer type in lean, but not obese, mice.
Conditioned overconsumption is dependent on reinforcer type in lean, but not obese, mice.
复制标题
DOI：
10.1016/j.appet.2024.107355
复制
发表时间：
2024-07-01
期刊：
影响因子：
5.4
通讯作者：
Stern，Sarah A.
中科院分区：
文献类型：
--
作者：
Lewis-Sanders，Darielle;Bullich，Sebastien;Stern，Sarah A.
联想学习可以驱动许多不同类型的行为，包括食物消费。先前的研究表明，当老鼠饥饿时，食物传递的提示会导致这些提示在以后的时间里增加消耗。我们之前的研究表明，在雄性小鼠中，过量进食可以通过使用鼠粮颗粒的环境线索来驱动。在这里，我们通过检查可能影响情境条件下过度消耗训练结果的其他参数来扩展我们的发现。我们发现，这项任务在男性和女性身上同样有效，高脂肪饮食和Ensure巧克力奶昔等可口的物质有助于学习，并导致过度消费。令人惊讶的是，当在训练中使用蔗糖作为强化物时，老鼠并没有过度消耗，这表明营养成分是一个关键因素。有趣的是，我们还观察到饮食诱导的肥胖小鼠没有学会这项任务。总的来说，我们发现情境条件性过度消费可以在瘦弱的雄性和雌性小鼠中进行研究，并且具有多种强化类型。
Associative learning can drive many different types of behaviors, including food consumption. Previous studies have shown that cues paired with food delivery while mice are hungry will lead to increased consumption in the presence of those cues at later times. We previously showed that overconsumption can be driven in male mice by contextual cues, using chow pellets. Here we extended our findings by examining other parameters that may influence the outcome of context-conditioned overconsumption training. We found that the task worked equally well in males and females, and that palatable substances such as high-fat diet and Ensure chocolate milkshake supported learning and induced overconsumption. Surprisingly, mice did not overconsume when sucrose was used as the reinforcer during training, suggesting that nutritional content is a critical factor. Interestingly, we also observed that diet-induced obese mice did not learn the task. Overall, we find that context-conditioned overconsumption can be studied in lean male and female mice, and with multiple reinforcer types.