Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
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DOI：
10.1088/1361-6560/ab9159
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发表时间：
2020-11-07
影响因子：
3.5
通讯作者：
Krishnan, Sunil
中科院分区：
文献类型：
--
作者：
Schuemann, Jan;Bagley, Alexander F.;Krishnan, Sunil
该路线图概述了金属纳米颗粒（MNP）在放射治疗领域的潜在作用。MNP由广泛的材料（从钛，Z = 22到铋，Z = 83）和类似的广泛的潜在临床应用组成，包括诊断、治疗（辐射剂量增强剂、热疗诱导剂、药物递送载体、疫苗佐剂、光敏剂、免疫治疗增强剂）和治疗诊断（结合诊断和治疗），正在制造和评估。该路线图涵盖了这些主题的专家的贡献，总结了他们对当前状况和挑战的看法，以及应对这些挑战的预期技术进步。
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.