The Significance of External Limiting Membrane Status for Visual Acuity in Age-Related Macular Degeneration
The Significance of External Limiting Membrane Status for Visual Acuity in Age-Related Macular Degeneration
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DOI：
10.1016/j.ajo.2010.02.012
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发表时间：
2010-07-01
影响因子：
4.2
通讯作者：
Kurimoto, Yasuo
中科院分区：
文献类型：
--
作者：
Oishi, Akio;Hata, Masayuki;Kurimoto, Yasuo
目的：评价年龄相关性黄斑变性（AMD）中外限制膜（ELM）对视力（VA）的影响。设计：以医院为基础的横断面研究。方法：我们回顾性地回顾了158例接受光动力治疗的AMD患者的光谱域光学相干断层图像，并根据ELM的状态对其进行了分类：缺失、不连续或完整。我们同时评估了中央凹厚度、视网膜下液/肿块的存在或不存在、视网膜下色素上皮液/肿块的存在或不存在、内段/外段（IS/OS）交界处的状态，以及IS/OS交界处和视网膜色素上皮之间的中间线的状态。分析了各参数与VA之间的相关系数。结果：ELM状态与VA有较强的相关性（r = -0.75, P < .001），且高于IS/OS （r = -0.69, P < .001）。多因素分析显示，ELM状态是VA的最重要因素，其他与VA相关的参数包括年龄、中间线状态、是否存在视网膜下或视网膜下色素上皮纤维化。结论：ELM状态可能比is /OS状态在评估AMD患者视网膜形态和功能方面更有用。[J]中华眼科杂志，2010;32(5):379 - 379。(C) 2010年Elsevier Inc.版权所有。)
PURPOSE: To evaluate status of the external limiting membrane (ELM) as a contributor of visual acuity (VA) in age-related macular degeneration (AMD).DESIGN: Hospital-based, cross-sectional study.METHODS: We retrospectively reviewed spectral-domain optical coherence tomography images of 158 patients with AMD who had undergone photodynamic therapy and classified them based on the status of the ELM: absent, discontinuous, or complete. We simultaneously assessed foveal thickness, presence or absence of subretinal fluid/mass, presence or absence of subretinal pigment epithelium fluid/mass, status of the inner segment/outer segment (IS/OS) junction, and status of the intermediate line between the IS/OS junction and retinal pigment epithelium. Correlation coefficients between each parameter and VA were analyzed.RESULTS: There was a strong correlation between ELM status and VA (r = -0.75, P < .001), and that was higher than that of the IS/OS (r = -0.69, P < .001). Multivariate analysis showed that ELM status is the most important factor for VA. Other parameters that correlated with VA included age, status of the intermediate line, and presence of subretinal or subretinal pigment epithelium fibrosis. Foveal thickness showed V-shaped correlation, with the dividing line around 200 mu m.CONCLUSION: ELM status may be more useful than is IS/OS status in evaluation of retinal morphology and function in patients with AMD. (Am J Ophthalmol 2010;150: 27-32. (C) 2010 by Elsevier Inc. All rights reserved.)