Arsenic methylation and skin cancer risk in southwestern Taiwan
Arsenic methylation and skin cancer risk in southwestern Taiwan
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DOI：
10.1097/01.jom.0000058336.05741.e8
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发表时间：
2003-03-01
影响因子：
3.2
通讯作者：
Christiani, DC
中科院分区：
文献类型：
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作者：
Chen, YC;Guo, YLL;Christiani, DC
砷是一种已知的致癌物质，但特别缺乏低水平接触对健康影响的数据，以及甲基化能力对健康的重要性。我们在台湾西南部进行了一项病例对照研究（1996年至1999年，76例病例和224例对照），以探讨原发性和继发性砷甲基化指数（PMI和SMI），累积砷暴露（CAE）和皮肤癌风险之间的关系。与对照组相比，皮肤癌组报告了更多的阳光照射（P = 0.02）和较低的BMI（P = 0.03），以及较低的教育水平（P = 0.01）。皮肤癌患者和对照组在年龄、性别、吸烟和饮酒方面相似。如果SMI较低（小于或等于5），则CAE > 15 mg/L-年与增加相关。与CAE小于或等于2 mg/L-年相比，皮肤癌的风险（OR，7.48; 95% CI，1.65-33.99）。在PMI、SMI和CAE水平相同的情况下，与女性相比，男性患皮肤癌的风险更高（OR，4.04; 95%CI，1.46-11.22）。具有低SMI和高CAE的受试者具有显著增加的皮肤癌风险。男性在砷暴露和甲基化能力的各个阶层中患皮肤癌的风险均高于女性。
Arsenic is a known carcinogen, but data are especially lacking on the health effects of low-level exposure, and on the health significance of methylation ability. We conducted a case-control study (76 cases and 224 controls from 1996 to 1999) in southwestern Taiwan to explore the association among primary and secondary arsenic methylation index (PMI and SMI, respectively), cumulative arsenic exposure (CAE), and the risk of skin cancer. As compared with the controls, the skin cancer group reported more sun exposure (P = 0.02) and had a lower BMI (P = 0.03), as well as lower education level (P = 0.01). Skin cancer patients and controls were similar with regard to age, gender, smoking and alcohol consumption. Given a low SMI (less than or equal to5), CAE > 15 mg/L-year was associated with an increased. risk of skin cancer (OR, 7.48; 95% CI, 1.65-33.99) compared to a CAE less than or equal to2 mg/L-year. Given the same level of PMI, SMI, and CAE, men had a higher risk of skin cancer (OR, 4.04; 95% CI, 1.46-11.22) when compared to women. Subjects with low SMI and high CAE have a substantially increased risk of skin cancer. Males in all strata of arsenic exposure and methylation ability had a higher risk of skin cancer than women.