Anoctamin and transmembrane channel-like proteins are evolutionarily related.
Anoctamin and transmembrane channel-like proteins are evolutionarily related.
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DOI：
10.3892/ijmm_00000205
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发表时间：
2009-07
影响因子：
5.4
通讯作者：
Lee B
中科院分区：
文献类型：
--
作者：
Hahn Y;Kim DS;Pastan IH;Lee B
Anoctamin(ANO)家族是哺乳动物中由10个成员组成的跨膜蛋白，具有钙激活的氯离子通道活性。跨膜通道样蛋白(TMC)家族由8个成员组成，在哺乳动物中也是跨膜蛋白，其突变与多种人类疾病有关，如听力损失和疣状表皮发育不良。在这里，我们发现ANO和TMC蛋白具有很高的序列相似性，并且可能具有相同的膜拓扑结构，这表明这些蛋白在进化上是相关的。我们在这两个蛋白质家族之间发现了许多保守的氨基酸残基，特别是在跨膜结构域TM1、TM4-TM5和TM6-TM7的区域。这些发现表明，这些蛋白形成了一个大家族，我们称之为ANO/TMC超家族，TMC蛋白也可能作为氯离子或其他离子的通道发挥作用。ANO/TMC超家族蛋白几乎存在于所有不同的真核生物群体中，这表明该蛋白在真核细胞的离子动态平衡等重要生物学过程中发挥作用。
Anoctamin (ANO) family of proteins, consisting of 10 members in mammals, are transmembrane proteins that have Ca2+-activated Cl- channel activities. Transmembrane channel-like (TMC) family of proteins, consisting of 8 members in mammals, are also transmembrane proteins of which mutations are implicated in various human conditions, such as hearing loss and epidermodysplasia verruciformis. Here we show that ANO and TMC proteins share high sequence similarity and probably the same membrane topology, indicating that these proteins are evolutionarily related. We found many conserved amino acid residues between the two families of proteins, especially in regions spanning the transmembrane domains TM1, TM4-TM5, and TM6-TM7. These findings imply that these proteins form one large family, which we term ANO/TMC superfamily and that TMC proteins may also function as channels for Cl- or possibly other ions. The ANO/TMC superfamily proteins are present in almost all the diverse groups of eukaryotic organisms, suggesting that the proteins function in important biological processes, such as ion homeostasis, in eukaryotic cells.
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