EFFECTS OF ANESTHESIA ON ACUTE ISCHEMIC ARRHYTHMIAS AND EPICARDIAL ELECTROGRAMS IN THE PIG-HEART INSITU
EFFECTS OF ANESTHESIA ON ACUTE ISCHEMIC ARRHYTHMIAS AND EPICARDIAL ELECTROGRAMS IN THE PIG-HEART INSITU
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DOI：
10.1093/cvr/24.3.227
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发表时间：
1990-03-01
影响因子：
10.8
通讯作者：
SCHOENENBERGER, A
中科院分区：
文献类型：
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作者：
BARDAJI, A;CINCA, J;SCHOENENBERGER, A
研究目的-本研究的目的是评估全身麻醉对左前降支冠状动脉闭塞的心电图和致心律失常反应的影响。设计-用α麻醉重18 - 20 kg的猪。氯醛糖100 mg. kg-1（n = 9）或硫喷妥钠30 mg. kg-1（n = 9），在60 min内每5 min连续测量一次心电图，每分钟分析一次心律失常，观察冠状动脉闭塞的致心律失常作用。结果-α氯醛糖易导致较低的ST段抬高（重复测量的方差分析p <0.002），心外膜传导延迟较不明显（p <0.01），但向双相电位的进展较慢，相反，室性早搏发作次数较多（p <0.005）、室性心动过速（51对32次发作）和心室颤动（6对2只猪）。结论-α氯醛糖和巴比妥类药物在猪急性心肌缺血模型中产生相反的心电图和致心律失常作用。由于氯醛糖的促心律失常作用，可能应用于处理自发性和诱导性缺血性心律失常的研究。
Study objective - The aim of the study was to assess the influence of general anaesthesia on electrocardiographic and arrhythmogenic responses to left anterior descending coronary artery occlusion. Design - Pigs weighing 18-20 kg were anaesthetised with .alpha. chloralose 100 mg .cntdot. kg-1 (n = 9) or thiopentone 30 mg .cntdot. kg-1 (n = 9) and the arrhythmogenic effects of coronary artery occlusion were examined by sequential electrocardiographic measurements every 5 min and arrhythmia analysis every minute over a 60 min period. Results - .alpha. Chloralose predisposed to lower ST segment elevation (analysis of variance for repeated measurements p < 0.002), less marked epicardial conduction delay (p < 0.01) with slower progression to monophasic potentials, and in contrast, to a greater number of episodes of ventricular premature beats (p < 0.005), ventricular tachycardia (51 v 32 episodes), and ventricular fibrillation (6 v 2 pigs) than barbiturate anaesthesia. Conclusions - .alpha. Chloralose and barbiturates exerted opposite electrocardiographic and arrhythmogenic effects in a porcine model of acute myocardial ischaemia. Due to its proarrhythmic effect chloralose should probably be used in studies dealing with spontaneous and induced ischaemic arrhythmias.