Adrenergic control of pineal N-acetyltransferase activity: developmental aspects.
Adrenergic control of pineal N-acetyltransferase activity: developmental aspects.
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松果体 N-乙酰转移酶活性的肾上腺素控制：发育方面。
DOI：
10.1152/ajpendo.1977.233.3.e141
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
J. Weller
中科院分区：
文献类型：
--
作者：
A. Yuwiler;D. Klein;M. Buda;J. Weller
新生大鼠的松果体N-乙酰基转移酶的活性没有表现出成年大鼠的大的日节律，并且介于成年大鼠的白天低值和夜间高值之间。这些中间值似乎是由肾上腺素能刺激引起的。阻断肾上腺素能受体或儿茶酚胺合成导致体内酶活性降低。在体外研究提供了额外的证据，一个完全发达的突触后肾上腺素能控制系统的松果体N-乙酰转移酶活性在出生时。我们的观察结果表明，松果体N-乙酰转移酶的昼夜节律的外观在生命的第一周结束时反映了突触前机制和结构的发展所需的控制儿茶酚胺的释放和吸收。这些事件遵循的突触后机制所需的调解肾上腺素能循环AMP调节松果体N-乙酰转移酶活性，这可以检测到出生前的发展外观。
The activity of pineal N-acetyltransferase in the neonatal rat does not exhibit the large daily rhythm seen in the adult and is intermediate between the low day and high night adult values. These intermediate values appear to result from adrenergic stimulation. Blockade of adrenergic receptors or of catecholamine synthesis results in a decrease in enzyme activity in vivo. In vitro studies provide additional evidence of a completely developed postsynaptic adrenergic control system for pineal N-acetyltransferase activity at birth. Our observations indicate that the appearance of a circadian rhythm in pineal N-acetyltransferase at the end of the first week of life reflects the development of presynaptic mechanisms and structures necessary for the control of catecholamine release and uptake. These events follow the developmental appearance of the postsynaptic mechanisms required to mediate the adrenergic-cycle AMP regulation of pineal N-acetyltransferase activity, which can be detected prior to birth.