Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS
Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS
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DOI：
10.1002/mrm.1910390110
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发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Frahm, J
中科院分区：
文献类型：
--
作者：
Pouwels, PJW;Frahm, J
在2.0 T下使用定量单体素质子MRS研究了年轻成年人的几个皮质白色和灰质区、小脑和丘脑中脑代谢物的区域分布，而神经元化合物N-乙酰天冬氨酸在整个脑中均匀分布，N-乙酰谷氨酸在尾部增加，并且在白色物质中的浓度高于灰质、肌酸、肌醇、谷氨酸、和谷氨酰胺在皮质白色物质中的浓度低于灰质。最高的肌酸水平被发现在小脑中，平行于肌酸激酶的分布和大脑中的能量需求过程，并且肌醇在小脑中具有最高的浓度。含胆碱化合物表现出显着的区域变异性，再次在小脑和最低水平的最高浓度和一个强大的尾部下降梯度的灰质。目前的研究结果既不支持代谢的性别差异（除了1.3倍高的肌醇水平在顶叶白色物质的女性受试者），也不是代谢半球不对称。
The regional distribution of brain metabolites was studied in several cortical white and gray matter areas, cerebellum, and thalamus of young adults with use of quantitative single-voxel proton MRS at 2.0 T, Whereas the neuronal compound N-acetylaspartate is distributed homogeneously throughout the brain, N-acetylaspartylglutamate increases caudally and exhibits higher concentrations in white matter than in gray matter, Creatine, myo-inositol, glutamate, and glutamine are less concentrated in cortical white matter than in gray matter. The highest creatine levels are found in cerebellum, parallel to the distribution of creatine kinase and energy-requiring processes in the brain, Also myo-inositol has highest concentrations in the cerebellum. Choline-containing compounds exhibit a marked regional variability with again highest concentrations in cerebellum and lowest levels and a strong caudally decreasing gradient in gray matter. The present findings neither support a metabolic gender difference (except for a 1.3-fold higher myo-inositol level in parietal white matter of female subjects) nor a metabolic hemispheric asymmetry.