Mortality in perinatally HIV-infected young people in England following transition to adult care: an HIV Young Persons Network (HYPNet) audit
Mortality in perinatally HIV-infected young people in England following transition to adult care: an HIV Young Persons Network (HYPNet) audit
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DOI：
10.1111/hiv.12091
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发表时间：
2014-04-01
期刊：
影响因子：
3
通讯作者：
Foster, C.
中科院分区：
文献类型：
--
作者：
Fish, R.;Judd, A.;Foster, C.
在英国，围产期获得性HIV感染（PHIV）的年轻人转移到成人护理后的死亡率尚未确定。我们进行了多中心的审计，以建立死亡人数和相关的factors.MethodsFourteen成人诊所照顾感染的年轻人报告死亡人数到2011年9月30日的形式。死亡相匹配的合作艾滋病毒儿科研究，在英国/爱尔兰的艾滋病毒感染的儿童的临床数据库，描述临床特点，在儿科护理那些谁死后transition.Results11例死亡，从14个诊所，照顾248名成年人与PHIV。在11例死亡病例中，转入成人护理时的中位年龄为17岁（范围15-21岁），死亡时的中位年龄为21岁（范围17-24岁）。死亡原因是自杀（2名患者）、晚期艾滋病毒疾病（7名患者）和支气管扩张（1名患者），其中1名患者的死因缺失。死亡时，中位CD 4计数为27个细胞/L（范围0-630个细胞/L）; 5名患者接受抗逆转录病毒治疗（ART），但只有2名患者有病毒载量
ObjectivesMortality in young people with perinatally acquired HIV infection (PHIV) following transfer to adult care has not been characterized in the UK. We conducted a multicentre audit to establish the number of deaths and associated factors.MethodsFourteen adult clinics caring for infected young people reported deaths to 30 September 2011 on a proforma. Deaths were matched to the Collaborative HIV Paediatric Study, a clinical database of HIV-infected children in the UK/Ireland, to describe clinical characteristics in paediatric care of those who died post-transition.ResultsEleven deaths were reported from 14 clinics which cared for 248 adults with PHIV. For the 11 deaths, the median age at transfer to adult care was 17 years (range 15-21 years), and at death was 21 years (range 17-24 years). Causes of death were suicide (two patients), advanced HIV disease (seven patients) and bronchiectasis (one patient), with one cause missing. At death, the median CD4 count was 27 cells/L (range 0-630 cells/L); five patients were on antiretroviral therapy (ART) but only two had a viral load