Effect of menopause on cognitive performance in women with Down syndrome.
Effect of menopause on cognitive performance in women with Down syndrome.
复制标题
更年期对唐氏综合症女性认知能力的影响。
DOI：
10.1097/00001756-200108280-00014
复制
发表时间：
2001
期刊：
影响因子：
1.7
通讯作者：
Schupf,N
中科院分区：
文献类型：
--
作者：
Patel,BN;Seltzer,GB;Wu,HS;Schupf,N
We compared cognitive function in nondemented pre-and postmenopausal women with Down syndrome, aged 21–57 years, with their age-matched male peers. The Woodcock–Johnson Tests of Cognitive Ability–Revised were used to assess cognitive function at baseline and 2 years later. Premenopausal women performed better than their age-matched male peers, while postmenopausal women performed more poorly than age-matched male peers (p= 0.007). Premenopausal women and young men showed no significant declines in cognition over time. Postmenopausal women, but not their age-matched male peers, showed significant declines in cognitive function. Our results support the hypothesis that cognitive declines in postmenopausal women are associated with estrogen deficiency rather than with age.
