STUDIES OF ANTICATARACT DRUGS FROM NATURAL SOURCES .1. EFFECTS OF A METHANOLIC EXTRACT AND THE ALKALOIDAL COMPONENTS FROM CORYDALIS TUBER ON IN-VITRO ALDOSE REDUCTASE-ACTIVITY
STUDIES OF ANTICATARACT DRUGS FROM NATURAL SOURCES .1. EFFECTS OF A METHANOLIC EXTRACT AND THE ALKALOIDAL COMPONENTS FROM CORYDALIS TUBER ON IN-VITRO ALDOSE REDUCTASE-ACTIVITY
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DOI：
10.1248/bpb.17.458
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发表时间：
1994-03-01
影响因子：
2
通讯作者：
TANAKA, T
中科院分区：
文献类型：
--
作者：
KUBO, M;MATSUDA, H;TANAKA, T
本文研究了延胡索（Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et c.c.h HSU）对大鼠粗晶状体醛糖还原酶（一种与糖尿病并发症有关的酶）的抑制作用。甲醇提取物（CM-ext）对醛糖还原酶有抑制作用，而水提取物（CA-ext）对醛糖还原酶无抑制作用。从CM-ext中分离的7种生物碱成分中，只有脱氢堇青碱能抑制醛糖还原酶。提示CM-ext对醛糖还原酶的抑制作用可能与脱氢紫碱有关。
The inhibitory effect of Corydalis tuber (Corydalis turtschaninovii BESSER forma yanhusuo Y. H. CHOU et C. C. HSU) was tested on crude rat lens aldose reductase, an enzyme involved in the complications of diabetes. The methanolic extract (CM-ext) inhibited aldose reductase, while the aqueous extract (CA-ext) was ineffective. Only dehydrocorydaline, of the seven alkaloidal components isolated from CM-ext, inhibited aldose reductase. It is suggested that the inhibitory effect of CM-ext on aldose reductase may be partially attributed to dehydrocorydaline.