REGULATION OF SKELETAL-MUSCLE FIBER SIZE, SHAPE AND FUNCTION
REGULATION OF SKELETAL-MUSCLE FIBER SIZE, SHAPE AND FUNCTION
复制标题
DOI：
10.1016/0021-9290(91)90383-x
复制
发表时间：
1991-01-01
影响因子：
2.4
通讯作者：
ROY, RR
中科院分区：
文献类型：
--
作者：
EDGERTON, VR;ROY, RR
有令人信服的证据表明，骨骼肌纤维的横截面积、表达的肌球蛋白类型、氧化磷酸化的潜力和肌核数量密切相关。这些变量中的每一个以及纤维的形状都具有可识别的生理后果。此外，表明细胞质与肌核的比率是肌球蛋白类型以及蛋白质合成和降解的量和/或速率的函数。尽管神经肌肉活动（肌电活动）以及相关的机械和代谢事件对蛋白质代谢具有显着的调节影响，但还有其他独立于这些活动相关事件的重要调节因素。活动和非活动相关的调节机制可能通过一系列细胞事件发生。发生的细胞反应的特定组合可以定义对特定蛋白质的调节作用的性质。尽管蛋白质调节的调节机制以及这些反应如何在结构上整合到功能纤维中或从功能纤维中去除的复杂性，建议当考虑纤维和肌肉的大小和形状时，可以更准确地定义和解释人类神经肌肉功能的对照研究。
There is convincing evidence that the cross-sectional area, the type of myosin expressed, the potential for oxidative phosphorylation and the number of myonuclei of a skeletal muscle fiber are closely interdependent. Each of these variables, as well as the shape of the fiber, has identifiable physiological consequences. Further, it is suggested that the cytoplasmic to myonucleus ratio is a function of the myosin type and the amount and/or rate of protein synthesis and degradation. Although the neuromuscular activity (electromyographic activity) as well as the associated mechanical and metabolic events have significant regulatory influences on protein metabolism, there are other important regulatory factors independent of these activity-related events. Both the activity and non-activity related regulatory mechanisms probably occur via a cascade of cellular events. The specific combinations of cellular responses that occur may define the nature of the modulatory effects on specific proteins. In spite of the complexity of the regulatory mechanisms of protein modulation and how these responses are structurally integrated into or removed from functional fibers, it is suggested that controlled studies of human neuromuscular function can be more accurately defined and interpreted when fiber and muscle size and shape are considered.