Hydrogen protects auditory hair cells from free radicals
Hydrogen protects auditory hair cells from free radicals
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DOI：
10.1097/wnr.0b013e32832a5c68
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发表时间：
2009-05-06
期刊：
影响因子：
1.7
通讯作者：
Ito, Juichi
中科院分区：
文献类型：
--
作者：
Kikkawa, Yayoi S.;Nakagawa, Takayuki;Ito, Juichi
活性氧（ROS）在老化、噪声损伤或耳毒性药物引起的听毛细胞变性中起重要作用。氢化是生物体中的基本还原/脱氧反应。因此，本研究探讨了氢保护听毛细胞免受ROS诱导的损伤的潜力。为了产生活性氧，我们应用抗霉素A的外植体培养的听觉上皮细胞，并检查氢的保护毛细胞对活性氧的影响。孵育与氢饱和的介质显着减少了ROS的产生和随后的脂质过氧化作用的听觉上皮细胞，导致毛细胞的存活率增加。这些发现显示了氢保护听毛细胞免受ROS诱导的损伤的潜力。NeuroReport 20：689-694（C）2009 Wolters Kluwer Health竖条Lippincott威廉姆斯& Wilkins.
Reactive oxygen species (ROS) play a role in the degeneration of auditory hair cells because of aging, noise trauma, or ototoxic drugs. Hydrogenation is a fundamental reduction/deoxidation reaction in living organisms. This study thus examined the potential of hydrogen to protect auditory hair cells from ROS-induced damage. To generate ROS, we applied antimycin A to explant cultures of auditory epithelia, and examined the effect of hydrogen on the protection of hair cells against ROS. Incubation with a hydrogen-saturated medium significantly reduced ROS generation and subsequent lipid peroxidation in the auditory epithelia, leading to increased survival of the hair cells. These findings show the potential of hydrogen to protect auditory hair cells from ROS-induced damage. NeuroReport 20:689-694 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.