Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: A resting-state fMRI study
Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: A resting-state fMRI study
复制标题
强迫症患者脑功能缺陷的定位：静息态功能磁共振成像研究。
DOI：
10.1016/j.jad.2012.01.022
复制
发表时间：
2012-05-01
影响因子：
6.6
通讯作者：
Li, Haitao
中科院分区：
文献类型：
--
作者：
Hou, Jingming;Wu, Wenjing;Li, Haitao
背景：强迫症(OCD)患者眼眶前额-纹状体环路异常被认为是可能的。本研究的目的是通过静息状态功能磁共振成像(FMRI)验证强迫症患者眼眶-纹状体环路的异常假说，探索强迫症患者是否存在其他脑区功能障碍，并进一步探讨强迫症患者基于体素的自发性神经元活动与临床特征的关系。方法：对23例强迫症患者和23名年龄性别匹配的正常对照进行静息状态功能磁共振检查，并用低频波动幅度(Alff)法对fMRI数据进行分析。结果：与正常对照组相比，强迫症患者双侧眶前叶皮质(OFC)的Alff增加。结果：与正常对照组相比，强迫症患者双侧眶前叶皮质的Alff增加。双侧小脑和顶叶皮质的前扣带回(ACC)和ALFF降低(P
Background: Abnormality of orbitofronto-striatal circuits was postulated in obsessive-compulsive disorder (OCD). The aim of this study is to test the abnormality hypothesis of orbitofronto-striatal circuits and explore whether there are any other dysfunctional brain regions in OCD using a resting-state functional magnetic resonance imaging (fMRI), and further investigate the relationship between the whole-brain voxel-based spontaneous neuronal activity of patients with OCD and clinical characteristics.Methods: 23 patients with OCD and 23 age- and gender-matched normal controls were examined using resting-state fMRI, and amplitude of low-frequency fluctuation (ALFF) approach was used to analyze fMRI data.Results: Compared with normal controls, patients with OCD presented increased ALFF in the bilateral orbitofrontal cortex (OFC), anterior cingulate cortex (ACC) as well as decreased ALFF in the bilateral cerebellum and parietal cortex (P