MODIFICATION OF STIMULATED LACRIMAL GLAND FLOW BY SYMPATHETIC-NERVE IMPULSES IN RABBIT
MODIFICATION OF STIMULATED LACRIMAL GLAND FLOW BY SYMPATHETIC-NERVE IMPULSES IN RABBIT
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DOI：
10.1152/ajplegacy.1976.230.1.80
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发表时间：
1976-01-01
影响因子：
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通讯作者：
DEPALAU, A
中科院分区：
文献类型：
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作者：
BOTELHO, SY;MARTINEZ, EV;DEPALAU, A
本研究是为了确定交感神经冲动是否改变泪腺液（LGF）流量，这是连续记录从套管在泪腺排泄管在兔麻醉与戊巴比妥钠。在毛果芸香碱诱导和反射诱导的分泌过程中，用电刺激上级颈神经节的节前干。当刺激前LGF流量大于3.0穆尔/min时，刺激强度等于或大于产生最大瞳孔扩张的强度的6-8倍，引起抑制，然后刺激后LGF流量增强。当刺激前LGF流量小于0.8穆尔/min时，较强的刺激增强LGF流量，但较弱的刺激产生抑制，然后刺激后LGF流量增强。虽然没有测量泪腺血流量，但在α和β肾上腺素能阻滞期间发生的这些反应的变化与在其他器官中α和β阻滞期间发生的交感神经诱导血流量的变化一致。
This study was undertaken to determine if sympathetic nerve impulses modify lacrimal gland fluid (LGF) flow, which was continuously recorded from a cannula in the excretory duct of the lacrimal gland in rabbits anesthetized with pentobarbital sodium. The preganglionic trunk of the superior cervical ganglion was stimulated with electrical stimuli during pilocarpine-induced and reflexly induced secretion. Stimuli equal to or 6-8 times stronger than the intensity that produced maximal pupil dilation caused inhibition followed by poststimulus enhancement of LGF flow when the prestimulus LGF flow was greater than 3.0 mul/min. When the prestimulus LGF flow was less than 0.8 mul/min, the stronger stimulation enhanced LGF flow but the weaker stimulation produced inhibition followed by poststimulus enhancement of LGF flow. Although no measurements of lacrimal gland blood flow were made, the alterations in these responses, which occurred during alpha- and beta-adrenergic blockade, were consistent with the changes in sympathetically induced blood flow that occur during alpha- and beta-blockade in other organs.