Recent developments in phototherapy: treatment methods and devices.
Recent developments in phototherapy: treatment methods and devices.
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DOI：
10.2174/187221308784543665
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发表时间：
2008-05
影响因子：
4.2
通讯作者：
A. Morita;M. Weiss;A. Maeda
中科院分区：
文献类型：
--
作者：
A. Morita;M. Weiss;A. Maeda
我们回顾最近获得专利的方法和设备，允许更有效地有针对性的光疗，副作用更少。在这里审查的新设备和方法是窄带UVB（311- 313 nm）与平面型光源和新的氯化氙准分子光（308 nm），这两种都允许有针对性的点照射，限制健康皮肤不必要的暴露于紫外线。一些新设备旨在选择性照射目标鼻和口腔粘膜组织，并提供受控剂量的紫外线。提供靶向光疗的设备减弱治疗引起的皮肤温度升高，从而减少组织损伤并增加皮肤对高UV剂量的耐受性。其他最近获得专利的方法包括使用辐射功效增强剂，如维生素D原及其类似物的局部制剂，然后用紫外线和/或蓝光照射。组合光疗和电疗疗法也可用于治疗选定的皮肤区域。这些新的方法和设备旨在提高光疗，特别是靶向光疗的安全性和有效性。
We review recently patented methods and devices that allow for more effectively targeted phototherapy with fewer side effects. Among the new devices and methods reviewed here are narrow-band UVB (311- 313 nm) with a flat-type light source and the new xenon chloride excimer light (308 nm), both of which allow for targeted spot irradiation, limiting the unnecessary exposure of healthy skin to UV light. Some new devices are designed to selectively irradiate targeted nasal and oral mucosal tissue and to deliver controlled doses of UV light. Devices that provide targeted phototherapy attenuate treatment-induced increases in skin temperature, thereby reducing tissue damage and increasing skin tolerance to high UV doses. Other recently patented methods include the use of irradiation efficacy enhancers, such as topical formulations of provitamin D and its analogs, followed by irradiation with UV and/or blue light. Combined phototherapy and electrotherapy therapy can also be used to treat selected skin areas. These new methods and devices are aimed at improving the safety and efficacy of phototherapy, especially targeted phototherapy.