CD247 expression is associated with differentiation and classification in ovarian cancer
CD247 expression is associated with differentiation and classification in ovarian cancer
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DOI：
10.1097/md.0000000000018407
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发表时间：
2019-12-01
期刊：
影响因子：
1.6
通讯作者：
Jiang, Jingting
中科院分区：
文献类型：
--
作者：
Ye, Wenfeng;Zhou, Yi;Jiang, Jingting
卵巢癌（Ovarian cancer，OC）是女性生殖系统最常见的恶性肿瘤之一，大多数卵巢癌确诊时已是晚期，5年生存率低于40%。CD 247的功能是增强T细胞抗原受体（TCR）信号级联，并在T淋巴细胞表面组装TCR/CD 3复合物。CD 247（+）T淋巴细胞在卵巢囊肿和卵巢囊肿中的表达差异有统计学意义（P < 0. 05），CD 247（+）T淋巴细胞在卵巢囊肿中的表达差异有统计学意义（P < 0. 05）。本研究采用免疫组化方法检测上皮型OC中CD 247的表达，并分析其与临床病理特征的关系。与卵巢囊肿患者相比，OC患者的外周血淋巴细胞减少，并且与癌组织相比，肿瘤浸润淋巴细胞中CD 247的表达减少。结果表明，CD 247的异常表达与OC的分化程度和分型有关，提示CD 247靶向治疗可作为OC的潜在治疗策略。
Ovarian cancer (OC) is one of the most common malignant tumors in female reproductive system and most OC cases are diagnosed at an advanced stage with the overall 5-year survival rate below 40%. The function of CD247 enhances T-cell antigen receptor (TCR) signaling cascade and it is necessary for assembling of the TCR/CD3 complex on the surface of T lymphocytes. It is well established that defective CD247 function leads to impaired activation of T cells upon engagement of the TCR.Flow cytometry was used to examine the difference of CD247(+) T lymphocyte between the OC and ovarian cyst, immunohistochemistry analysis was used to investigate the correlation between CD247 expression and clinicopathologic features of epithelial OC patients.Our study showed that the expression of CD247 in peripheral blood lymphocytes from patients with OC is decreased compared with ovarian cyst patients and the expression of CD247 in tumor infiltrating lymphocytes with cancer tissue is decreased compared with adjacent tissues. We showed that abnormal expression of CD247 was related with differentiation and classification in OC.Our findings suggested that CD247-targeted treatment could be used as a potential therapeutic strategy for OC.