CORONAVIRUS ANTIBODY TITERS IN SERA OF HEALTHY ADULTS AND EXPERIMENTALLY INFECTED VOLUNTEERS
CORONAVIRUS ANTIBODY TITERS IN SERA OF HEALTHY ADULTS AND EXPERIMENTALLY INFECTED VOLUNTEERS
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DOI：
10.1017/s0022172400022294
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发表时间：
1972-01-01
期刊：
影响因子：
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通讯作者：
SOMERSET, BA
中科院分区：
文献类型：
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作者：
BRADBURNE, AF;SOMERSET, BA
在美国分离出的六种冠状病毒已经接种到志愿者身上，它们都产生了感冒。在这些和其他实验性冠状病毒感染后，10%至20%的受感染志愿者产生了异源抗体反应。用OC43病毒株进行血凝抑制试验，发现感染多种病毒株后抗体升高。对1965年至1970年间正常成人血清的研究表明，一种菌株（229E）的中和抗体频率很高，而菌株OC43的HI抗体频率每年波动。还发现了针对这两种病毒的补体固定抗体，揭示了1968年至1969年冬季英国普通人群中冠状病毒活性的明显增加。
Six coronaviruses isolated in the U.S.A. have been inoculated into volunteers and all produced colds. Between 10 and 20 % of infected volunteers developed heterologous antibody responses after these and other experimental infections with coronaviruses. The haemagglutination-inhibition test with the OC43 virus strain was found to detect antibody rises after infection with a variety of strains.Studies on normal adult sera taken between 1965 and 1970 revealed a high frequency of neutralizing antibody to one strain (229E) and a frequency of HI antibody to strain OC43 which fluctuated from year to year. Complement-fixing antibodies to these two viruses were also found, revealing an apparent increase in the activity of coronaviruses in the general population of the U.K., during the winter of 1968–9.