Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
Circadian genes Per1 and Per2 increase radiosensitivity of glioma in vivo
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DOI：
10.18632/oncotarget.3179
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发表时间：
2015-04-30
期刊：
影响因子：
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通讯作者：
Xia Hechun
中科院分区：
文献类型：
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作者：
Niu Zhanfeng;Li Yanhui;Xia Hechun
Per1 和 Per2 在调节哺乳动物的昼夜节律中发挥着关键作用。我们在此报告，尽管这两种基因在大鼠的神经胶质瘤和正常脑组织中都以昼夜节律表达，但它们的表达谱在两种类型的组织中有所不同。此外，神经胶质瘤组织中 Per1 和 Per2 的高表达与 X 射线照射的敏感性增加相关。在正常组织中没有观察到这种致敏作用。我们的结果表明 Per1 和 Per2 表达可能通过促进细胞凋亡来提高神经胶质瘤放疗的疗效。
Per1 and Per2 play a key role in regulating the circadian rhythm in mammals. We report here that although both genes were expressed with a circadian rhythm in glioma and normal brain tissue in rats, their expression profiles differed in the two types of tissue. In addition, high expression of Per1 and Per2 in glioma tissue was associated with increased sensitivity to x-irradiation. No such sensitizing effect was observed in normal tissue. Our results suggest that Per1 and Per2 expression may increase the efficacy of radiotherapy against glioma by promoting apoptosis.