REACTION OF NITRITE WITH ASCORBATE AND ITS RELATION TO NITROSAMINE FORMATION
REACTION OF NITRITE WITH ASCORBATE AND ITS RELATION TO NITROSAMINE FORMATION
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DOI：
10.1093/jnci/54.5.1203
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发表时间：
1975-01-01
期刊：
影响因子：
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通讯作者：
WEISMAN, M
中科院分区：
文献类型：
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作者：
ARCHER, MC;TANNENBAUM, SR;WEISMAN, M
在抗坏血酸存在下吗啉亚硝化反应的研究中，完全抑制亚硝基吗啉生成所需的抗坏血酸的量取决于体系中是否存在氧气。一氧化氮(在亚硝酸氧化抗坏血酸过程中产生)可能与氧反应生成额外的氧化当量，或者氧可能直接氧化在氧化反应的初始步骤中产生的抗坏血酸半醌中间体。在抗坏血酸和过量亚硝酸盐存在下的吗啉亚硝化反应中观察到了一个与pH有关的诱导期，反应的动力学可以解释。
In this study of the nitrosation of morpholine in the presence of ascorbic acid, the amount of ascorbate required to inhibit completely the formation of nitrosomorpholine depended on whether oxygen was present in the system. The nitric oxide (produced during the oxidation of ascorbate by nitrous acid) might have reacted with oxygen to yield additional oxidizing equivalents, or oxygen might have directly oxidized the ascorbate semiquinone intermediate produced in the initial step of oxidation reaction. A pH-dependent induction period observed during the nitrosation of morpholine in the presence of ascorbate and excess nitrite was accounted for by the kinetics of the reactions.