Regional brain stiffness changes across the Alzheimer's disease spectrum.
Regional brain stiffness changes across the Alzheimer's disease spectrum.
复制标题
整个阿尔茨海默氏病谱系中的区域大脑僵硬变化。
DOI：
10.1016/j.nicl.2015.12.007
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Huston J 3rd
中科院分区：
文献类型：
--
作者：
Murphy MC;Jones DT;Jack CR Jr;Glaser KJ;Senjem ML;Manduca A;Felmlee JP;Carter RE;Ehman RL;Huston J 3rd
磁共振弹性成像(MRE)是一种基于MRI的非侵入性测量组织硬度的技术。目前，MRE已被广泛用于肝脏的临床应用，作为一种新的神经系统疾病的生物标志物，MRE正越来越多地被用于测量脑僵硬。这项工作的目的是应用最近开发的MRE管道来测量整个阿尔茨海默病(AD)谱中受试者的局部脑僵硬变化，并通过将僵硬与AD现有的生物标记物相关联来深入了解这些僵硬变化背后的生物过程。结果表明，僵硬改变主要发生在额叶、顶叶和颞叶，这与AD病理的已知地形图相一致。此外，这些区域的僵硬与AD现有的成像生物标记物相关，包括海马体体积和淀粉样蛋白PET。进一步的分析显示，初步但重要的证据表明，大脑僵硬和AD严重程度之间的关系是非线性和非单调的。鉴于在功能磁共振实验中观察到了类似的关系，我们使用无任务功能磁共振数据来测试大脑僵硬对与功能连接改变相关的结构变化敏感的假设。分析表明，大脑僵硬与默认模式网络连接显著正相关。因此，MRE测量的脑僵硬有可能为AD的时间动力学以及与AD病理生理学相关的功能可塑性和结构可塑性之间的关系提供新的和必要的见解。阿尔茨海默病引起的大脑僵硬的改变是地区性的。大脑僵硬与疾病严重程度的既定衡量标准有关。在整个疾病谱中，大脑僵硬的变化似乎不是单调的。刚性与默认模式网络功能连通性相关。
Magnetic resonance elastography (MRE) is an MRI-based technique to noninvasively measure tissue stiffness. Currently well established for clinical use in the liver, MRE is increasingly being investigated to measure brain stiffness as a novel biomarker of a variety of neurological diseases. The purpose of this work was to apply a recently developed MRE pipeline to measure regional brain stiffness changes in human subjects across the Alzheimer's disease (AD) spectrum, and to gain insights into the biological processes underlying those stiffness changes by correlating stiffness with existing biomarkers of AD. The results indicate that stiffness changes occur mostly in the frontal, parietal and temporal lobes, in accordance with the known topography of AD pathology. Furthermore, stiffness in those areas correlates with existing imaging biomarkers of AD including hippocampal volumes and amyloid PET. Additional analysis revealed preliminary but significant evidence that the relationship between brain stiffness and AD severity is nonlinear and non-monotonic. Given that similar relationships have been observed in functional MRI experiments, we used task-free fMRI data to test the hypothesis that brain stiffness was sensitive to structural changes associated with altered functional connectivity. The analysis revealed that brain stiffness is significantly and positively correlated with default mode network connectivity. Therefore, brain stiffness as measured by MRE has potential to provide new and essential insights into the temporal dynamics of AD, as well as the relationship between functional and structural plasticity as it relates to AD pathophysiology. Alterations in brain stiffness due to Alzheimer's disease are regionally specific. Brain stiffness is associated with established measures of disease severity. Brain stiffness changes appear non-monotonic across the disease spectrum. Stiffness is correlated with default mode network functional connectivity.