IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjögren's syndrome and rheumatoid arthritis.
IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjögren's syndrome and rheumatoid arthritis.
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DOI：
10.1006/clin.1998.4520
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发表时间：
1998-06
期刊：
影响因子：
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通讯作者：
S. Perrier;C. Coussediere;J. Dubost;É. Albuisson;B. Sauvezie
中科院分区：
文献类型：
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作者：
S. Perrier;C. Coussediere;J. Dubost;É. Albuisson;B. Sauvezie
编码白介素-1受体拮抗剂（IL-1ra）的基因具有可变的等位基因多态性。IL1RN*2等位基因最近被描述为几种自身免疫性疾病的一个严重因素，并且在体外与单核细胞IL-1ra产生增加矛盾地相关。我们在36例可能或确定的原发性Sjögren综合征患者中研究了这种多态性，发现明确形式的IL1RN*2明显多于可能形式的IL1RN*2。在类风湿关节炎中，该等位基因的频率与对照组没有差异。Sjögren患者血清IL-1ra水平明显高于健康人。相比之下，唾液IL-1ra水平降低。与没有该等位基因的患者相比，携带该等位基因的患者通常唾液水平较低，血清水平较高。在有明确综合征的患者组中，CRP和tgf - β 1这两种体外刺激IL-1ra产生的物质与IL-1ra血清水平相关。我们的研究结果表明，IL1RN*2是Sjögren综合征更严重形式的标志。其对唾液和血清IL-1ra的影响可能不同，提示不同的调节机制。
The gene encoding interleukin-1 receptor antagonist (IL-1ra) has a variable allelic polymorphism. The IL1RN*2 allele was recently described as a factor of severity in several autoimmune diseases and was paradoxically associated with increased production of IL-1ra by monocytes in vitro. We studied this polymorphism in 36 patients with possible or definite primary Sjögren's syndrome and found that IL1RN*2 was significantly more frequent in the definite than in the possible form. In rheumatoid arthritis, the frequency of the allele was not different from that of controls. The serum levels of IL-1ra were markedly higher in Sjögren patients than in those of healthy subjects. By contrast, the salivary IL-1ra levels were decreased. Patients with the allele generally had lower salivary levels and higher serum levels than patients without the allele. In the group of patients with the definite syndrome, CRP and TGF-beta 1, two in vitro stimulators of IL-1ra production, were correlated with IL-1ra serum levels. Our results suggest that IL1RN*2 is a marker of more severe forms of Sjögren's syndrome. Its effect on salivary and serum IL-1ra may be distinct, suggesting separate regulatory mechanisms.