Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs
Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs
复制标题
Hoxc-9突变小鼠显示椎骨前部转化以及胸骨和肋骨畸形
DOI：
10.1016/0925-4773(95)00371-1
复制
发表时间：
1995
影响因子：
2.6
通讯作者：
S. Noguchi
中科院分区：
文献类型：
--
作者：
H. Suemori;N. Takahashi;S. Noguchi
为了阐明Hoxc-9基因的功能，我们通过基因打靶将突变引入Hoxc-9位点。对纯合子的skeleton分析显示，前向同源异型转化发生在第10胸椎到第1腰椎。观察肋骨的弯曲和融合。胸骨上有八九对肋骨。胸骨显示出异常的骨化。突变小鼠的表型与Hoxc-8突变小鼠的表型相似。这些数据表明，Hoxc-8和Hoxc-9蛋白之间的功能相互作用参与了节段决定。此外，Hoxc-8基因表达模式的变化表明Hoxc-9基因调节Hoxc-8基因的表达。
To clarify the function of the Hoxc-9 gene, we have introduced a mutation into the Hoxc-9 locus by gene targeting. Skeletal analysis of homozygotes revealed that anterior homeotic transformation occurred from the 10th thoracic vertebra to the first lumbar vertebra. Bending and fusion of the ribs were observed. Eight or nine pairs of ribs were attached to the sternum. The sternum showed an abnormal pattern of ossification. Phenotypes of the mutant mice resembled those of the Hoxc-8 mutant mice. The data suggested that a functional interaction between the Hoxc-8 and Hoxc-9 proteins is involved in segmental determination. Moreover, changes in the Hoxc-8 gene expression pattern suggested that the Hoxc-9 gene regulates expression of the Hoxc-8 gene.
影响因子：
10.5
作者：
SMALL, KM;POTTER, SS
通讯作者：
POTTER, SS