Wear particles
Wear particles
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DOI：
10.2106/jbjs.f.00102
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发表时间：
2006-01-01
影响因子：
5.3
通讯作者：
Wimmer, MA
中科院分区：
文献类型：
--
作者：
Jacobs, JJ;Hallab, NJ;Wimmer, MA
全关节置换部件体内降解产生的颗粒和离子碎片被认为是限制关节重建寿命和手术总体成功的主要因素。颗粒和离子磨损和腐蚀碎屑与局部侵袭性生物反应有关，可导致滑膜炎、假体周围骨丢失和植入物无菌性松动。此外，人们还担心假体碎片的全身性扩散，包括终末器官滞留造成的潜在影响。全椎间盘置换术的长期成功可能很大程度上取决于（至少部分取决于）减少植入物碎片产生以及随后的局部和全身反应的能力。
Particulate and ionic debris resulting from in vivo degradation of total joint replacement components are recognized as major factors limiting the longevity of the joint reconstruction and the overall success of the procedure. Particulate and ionic wear and corrosion debris have been associated with a locally aggressive biologic response that can lead to synovitis, periprosthetic bone loss, and aseptic loosening of the implants. Furthermore, concerns exist regarding the systemic dissemination of prosthetic debris, including potential effects resulting from end-organ retention. The long-term success of total disc arthroplasty may well depend, at least in part, on the ability to minimize implant debris generation and the subsequent local and systemic response.