Contrasts for Identifying the Minimum Effective Dose

Contrasts for Identifying the Minimum Effective Dose
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确定最低有效剂量的对比

DOI:
10.1080/01621459.1989.10478843
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发表时间:
1989
影响因子:
3.7
通讯作者:
S. Ruberg
S. Ruberg
中科院分区:
数学1区
文献类型:
--
作者:
S. Ruberg

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摘要剂量-反应研究常用于研究实验化合物对各种反应的影响。通常感兴趣的化合物的一个特征是最小有效剂量(MED)。通常,通过比较不同剂量组与对照组得出MED的推断(Dunnett 1955;威廉姆斯1971)。本文探讨了两个家庭的对比用于相关的问题,并提出了一个新的家庭的对比(称为盆对比),专门用于识别MED。蒙特卡罗研究被用来证明的对比程序的优越性,并提出建议,为他们的使用。
Abstract Dose-response studies are frequently used to study the effects of an experimental compound on various responses. One characteristic of the compound that is frequently of interest is the minimum effective dose (MED). Generally, inference about the MED is made by comparing various dose groups with a control (Dunnett 1955; Williams 1971). This article examines two families of contrasts used for related problems, and proposes a new family of contrasts (called basin contrasts) designed specifically for identifying the MED. Monte Carlo studies are used to demonstrate the superiority of the contrast procedures and make recommendations for their use.
DOI: 10.2307/2531545
发表时间: 1987-12-01
期刊: BIOMETRICS
影响因子: 1.9
作者:
EDWARDS, D;BERRY, JJ
通讯作者: BERRY, JJ