Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.
Postprandial ghrelin, cholecystokinin, peptide YY, and appetite before and after weight loss in overweight women with and without polycystic ovary syndrome.
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DOI：
10.1093/ajcn/86.5.1603
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发表时间：
2007-12
期刊：
影响因子：
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通讯作者：
L. Moran;M. Noakes;P. Clifton;G. Wittert;C. Le Roux;M. Ghatei;S. Bloom;R. Norman
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文献类型：
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作者：
L. Moran;M. Noakes;P. Clifton;G. Wittert;C. Le Roux;M. Ghatei;S. Bloom;R. Norman
多囊卵巢综合征（PCOS）是一种与肥胖、生殖和代谢功能障碍相关的常见疾病。多囊卵巢综合征患者食欲调节异常可能导致体重管理困难。目的：我们的目的是检查体重减轻前后伴有和不伴有多囊卵巢综合征的超重女性的食欲、食欲激素和随意进食情况。设计年龄和体重匹配的多囊卵巢综合征（n = 14）和非多囊卵巢综合征（n = 14）的超重女性接受8周的能量限制饮食（5185.3 +/- 141.6千焦/天）。在基线和研究结束时，受试者消耗一顿测试餐（936kj； 25%的能量来自蛋白质，9%来自脂肪，67%来自碳水化合物）。在0、15、30、45、60、90、120和180分钟时评估主观食欲和循环葡萄糖、胰岛素、胃饥饿素、胆囊收缩素和YY肽。然后提供混合自助餐午餐来评估随意食物摄入量。结果两组患者体重减轻（4.2 +/- 3.9 kg）无显著差异。与未患多囊卵巢综合征的女性相比，患有多囊卵巢综合征的女性在减肥前后的胃饥饿素浓度显著降低（P = 0.023）。PCOS患者餐后胃饥饿素抑制程度在第0周（P = 0.048）和第8周（P = 0.069）时均低于非PCOS患者。两组在减肥前后的食欲反应、自助餐消费、空腹或餐后肽YY和胆囊收缩素均无显著差异。结论：多囊卵巢综合征与减肥前后空腹胃饥饿素降低和餐后胃饥饿素抑制相关，但与其他餐后肠道肽、主观饱腹感或食物摄入无关。目前尚不清楚多囊卵巢综合征患者的食欲调节是否受损。
BACKGROUND Polycystic ovary syndrome (PCOS) is a common condition associated with obesity and with reproductive and metabolic dysfunction. Abnormalities in appetite regulation in PCOS patients may contribute to difficulties in weight management. OBJECTIVE We aimed to examine appetite, appetite hormones, and ad libitum food consumption before and after weight loss in overweight women with and without PCOS. DESIGN Overweight age- and weight-matched women with (n = 14) and without (n = 14) PCOS undertook an 8-wk energy-restricted diet (5185.3 +/- 141.6 kJ/d). At baseline and study end, subjects consumed a test meal (936 kJ; 25% of energy from protein, 9% from fat, and 67% from carbohydrate). Subjective appetite and circulating glucose, insulin, ghrelin, cholecystokinin, and peptide YY were assessed at 0, 15, 30, 45, 60, 90, 120, and 180 min. A mixed buffet lunch was then offered to assess ad libitum food intake. RESULTS Weight loss (4.2 +/- 3.9 kg) did not differ significantly between the 2 groups. Women with PCOS had significantly (P = 0.023) lower ghrelin concentrations before and after weight loss than did women without PCOS. The degree of postprandial ghrelin suppression was lower at weeks 0 (P = 0.048) and 8 (P = 0.069) in women with PCOS than in women without PCOS. There were no significant differences between the 2 groups in appetite responses, buffet consumption, or fasting or postprandial peptide YY and cholecystokinin before or after weight loss. CONCLUSIONS PCOS was associated with lower fasting ghrelin and a smaller postprandial ghrelin suppression both before and after weight loss but was not associated with other postprandial gut peptides, subjective satiety, or food intake. It is not clear whether appetite regulation is impaired in PCOS.