STUDIES OF RENAL OXYGEN CONSUMPTION IN MAN .1. THE EFFECT OF TUBULAR LOADING (PAH), WATER DIURESIS AND OSMOTIC (MANNITOL) DIURESIS
STUDIES OF RENAL OXYGEN CONSUMPTION IN MAN .1. THE EFFECT OF TUBULAR LOADING (PAH), WATER DIURESIS AND OSMOTIC (MANNITOL) DIURESIS
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DOI：
10.1172/jci102488
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发表时间：
1951-01-01
影响因子：
15.9
通讯作者：
BARKER, HG
中科院分区：
文献类型：
--
作者：
CLARK, JK;BARKER, HG
通过肾静脉插管清除技术，在（a）PAH（对氨基马尿酸盐）肾小管转运机制饱和、（B）水利尿和（c）甘露醇诱导的渗透性利尿之前和期间，测量了未麻醉男性的肾耗氧量。15例受试者的平均肾耗氧量为6.24 cc/100 g。标准偏差为2.07，平均值的标准误差为0.54。平均肾动静脉氧差为1.43vol. %标准偏差为0.39，平均值的标准误差为0.10。这些值与体外工作相当接近。对照组和试验组测量值之间的肾耗氧量无统计学显著性变化。这些数据表明，肾脏消耗的大部分氧气用于无法通过外部功测量的目的。这些数据表明，特殊饮食对肾脏疾病的任何有益结果都不是由于外部工作减少而导致的氧气需求减少，从而使肾脏休息。
By means of clearance technics with renal vein catheterization renal oxygen consumption has been measured in unanesthetized man before and during (a) saturation of the tubular transport mechanism for PAH (para-aminohippurate), (b) water diuresis, and (c) osmotic diuresis induced by mannitol. The mean renal oxygen consumption in 15 subjects was 6.24 cc/100 g./min. with a standard deviation of 2.07 and a standard error of the mean of 0.54. The mean renal arteriovenous oxygen difference was 1.43 vol.% with a standard deviation of 0.39 and a standard error of the mean of 0.10. These values are in reasonably close agreement with in vitro work. There was no statistically significant change in renal oxygen consumption between the control and test measurements. These data suggest that the bulk of oxygen consumed by the kidney is used for purposes not measurable by external work. The data suggest that any beneficial results of special diets in renal disease do not result from resting the kidney by decreasing the oxygen requirement as a result of diminution of external work.