Personality traits and cancer survival: a Danish cohort study
Personality traits and cancer survival: a Danish cohort study
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DOI：
10.1038/sj.bjc.6603244
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发表时间：
2006-07-17
影响因子：
8.8
通讯作者：
Johansen, C.
中科院分区：
文献类型：
--
作者：
Nakaya, N.;Hansen, P. E.;Johansen, C.
我们在丹麦进行了一项基于人群的前瞻性队列研究，以调查人格特质与癌症生存率之间的关系。在1976年至1977年期间，哥本哈根县的1020名居民完成了一份问卷调查，问卷内容涉及个性特征和各种健康习惯。采用艾森克人格问卷（简称Eysenck Personality Inventory）测量了被试的人格特质：外倾性和神经质。丹麦癌症登记处1976 - 2002年的随访显示189例原发性癌症事件，从癌症诊断之日起至2005年的死亡随访显示该组有82例全因死亡。采用考克斯比例风险模型，根据外倾性和神经质调整潜在混杂因素，估计全因死亡的风险比（HR）。神经质与死亡风险之间存在显著相关性（HR，2.3（95% CI = 1.1 - 4.7）;线性趋势P 0.04），但外向性与死亡风险之间无显著相关性（HR，0.9（0.4 - 1.7）;线性趋势P = 0.34）。当使用癌症相关死亡时也发现了类似的结果。按性别分层显示，女性神经质与死亡风险之间存在强正相关（线性趋势P = 0.03）。这项研究表明，神经质与癌症存活率呈正相关。需要进一步研究神经质和癌症存活率。
We conducted a population-based prospective cohort study in Denmark to investigate associations between the personality traits and cancer survival. Between 1976 and 1977, 1020 residents of the Copenhagen County completed a questionnaire eliciting information on personality traits and various health habits. The personality traits extraversion and neuroticism were measured using the short form of the Eysenck Personality Inventory. Follow- up in the Danish Cancer Registry for 1976 - 2002 revealed 189 incidents of primary cancer and follow-up for death from the date of the cancer diagnosis until 2005 revealed 82 deaths from all- cause in this group. A Cox proportional- hazards model was used to estimate the hazard ratios ( HRs) of death from all- cause according to extraversion and neuroticism adjusting for potential confounding factors. A significant association was found between neuroticism and risk of death ( HR, 2.3 ( 95% CI = 1.1 - 4.7); Linear trend P 0.04) but not between extraversion and risk of death ( HR, 0.9 ( 0.4 - 1.7); Linear trend P = 0.34). Similar results were found when using cancer- related death. Stratification by gender revealed a strong positive association between neuroticism and the risk of death among women ( Linear trend P = 0.03). This study showed that neuroticism is positively associated with cancer survival. Further research on neuroticism and cancer survival is needed.