A prospective analysis of the HOMA model - The Mexico City Diabetes Study
A prospective analysis of the HOMA model - The Mexico City Diabetes Study
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DOI：
10.2337/diacare.19.10.1138
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发表时间：
1996-10-01
期刊：
影响因子：
16.2
通讯作者：
Stern, MP
中科院分区：
文献类型：
--
作者：
Haffner, SM;Gonzalez, C;Stern, MP
目的：胰岛素抵抗（IR）和胰岛素分泌减少均可预测NIDDM的发展。然而，在流行病学研究中，评估胰岛素敏感性和分泌的方法复杂且昂贵。稳态模型评估（HOMA）已被建议作为一种评估IR和空腹血糖和胰岛素浓度分泌的方法。研究设计和方法：我们将HOMA模型应用于墨西哥城糖尿病研究的3.5年随访。结果：1449名受试者中，97人患糖尿病。当单独建模时，胰岛素抵抗而不是胰岛素分泌预测NIDDM。然而，当这两个变量进入同一回归模型时，IR升高和p细胞功能降低都能显著预测NIDDM。结论：我们得出结论，HOMA为流行病学研究中评估p细胞功能提供了一个有用的模型，并且在评估胰岛素分泌时考虑IR的程度是很重要的。
OBJECTIVE - Both insulin resistance (IR) and decreased insulin secretion have been shown to predict the development of NIDDM. However, methods to assess insulin sensitivity and secretion are complicated and expensive to apply in epidemiological studies. The homeostasis model assessment (HOMA) has been suggested as a method to assess IR and secretion from the fasting glucose and insulin concentrations.RESEARCH DESIGN AND METHODS - We applied the HOMA model in the 3.5-year follow-up of the Mexico City Diabetes Study.RESULTS - Out of 1,449 subjects, 97 developed diabetes. When modeled separately insulin resistance but not insulin secretion predicted NIDDM. However, when both variables were entered into the same regression model, both increased IR and decreased p-cell function significantly predicted NIDDM.CONCLUSIONS - we conclude that the HOMA provides a useful model to assess p-cell function in epidemiological studies and that it is important to take into account the degree of IR in assessing insulin secretion.