Punctal-canalicular stenosis related to systemic fluorouracil therapy.
Punctal-canalicular stenosis related to systemic fluorouracil therapy.
复制标题
与全身氟尿嘧啶治疗相关的泪小管狭窄。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
M. Zangmeister
中科院分区：
文献类型：
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作者：
L. Caravella;J. A. Burns;M. Zangmeister
据我们所知，这是眼科文献中第一例与长期应用氟尿嘧啶相关的点状泪小管狭窄和伴随溢泪的报告；据我们所知，氟尿嘧啶是第一种全身用药导致泪道系统阻塞的药物。对3名单独服用该抗代谢药物的患者以及1名与甲氨蝶呤和环磷酰胺联合治疗的患者进行了溢泪主诉的研究。所有四名患者都表现出一个或多个斑点的狭窄或闭塞，而三名患者的一个或四个小管也有狭窄。2例患者表现为复发溢泪，每次给药后1-2天开始，2-3天后消失。1例患者在导管系统硅胶管插管后症状改善。
This is, to our knowledge, the first report in the ophthalmic literature of punctal-canalicular stenosis and concomitant epiphora associated with the prolonged administration of fluorouracil; to our knowledge, fluorouracil is the first systemically administered agent to cause obstruction in the lacrimal system. Each of three patients receiving this antimetabolite alone and one patient receiving it in combination with methotrexate and cyclophosphamide were studied for complaints of epiphora. All four patients exhibited stenosis or occlusion of one or more puncta, while three also had one or four of their canaliculi stenosed. Two patients exhibited recurrent epiphora, beginning one to two days after each administration of fluorouracil and resolving in two to three days. One patient experienced amelioration of her symptoms after Silastic tube intubation of her canalicular system.