Or improvements to that in protein production
Or improvements to that in protein production
复制标题
或者改善蛋白质生产
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
フランコ、マルコ ロドリゲス
中科院分区：
文献类型：
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作者：
ゴル、ギルベルト;シュテメー、クリスティアーン;ラウンハルト、ヘイケ;フランコ、マルコ ロドリゲス
本发明通过将苔藓植物转化为酵母、纤毛虫或非动物真核细胞如藻类细胞，来生产一种糖基化异源蛋白的方法。具体地说，本方法是一种藻类植物细胞，例如细胞，其包括含有唾液酸残基的动物糖基化模式，例如用于人类等哺乳动物中的药物蛋白、生产糖化蛋白的方法、其所需的诸如DNA和RNA的遗传物质、载体、宿主细胞、在其中引入遗传物质的方法及其用途。本发明涉及根据本发明的方法获得的新型多肽和蛋白质。本发明还提供了一种生产唾液酸或CMP-唾液酸的方法。
The present invention, moss plants transformed, yeast, ciliate or non-animal eukaryotic cells such as algae cells, to a method of producing a glycosylated heterologous proteins. In particular, the present method is a Physcomitrella patens (Physcomitrella patens) moss plant cell, such as a cell, for example, comprising animal glycosylation pattern comprising a sialic acid residue, such as pharmaceuticals proteins for use in mammals such as humans, method of producing glycosylated proteins, genetic material such as DNA and RNA required therefor, vectors, host cells, methods of introducing genetic material therein, and uses thereof. The present invention relates to novel polypeptides and proteins obtained according to the process of the present invention. The invention further non-mammalian eukaryotic cells transformed, tissue, or organism, provides a method of producing sialic acid or CMP- sialic acid.