Effect of oral l-Glutamine supplementation on Covid-19 treatment.
Effect of oral l-Glutamine supplementation on Covid-19 treatment.
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DOI：
10.1016/j.yclnex.2020.07.003
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发表时间：
2020-10-01
影响因子：
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通讯作者：
Yavuzer, Serap
中科院分区：
文献类型：
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作者：
Cengiz, Mahir;Borku Uysal, Betul;Yavuzer, Serap
目的：探讨口服L谷氨酰胺对住院时间、重症监护病房需求及新冠肺炎病死率的影响。方法：对年龄、性别、临床状态相近的30例服用L谷氨酰胺的新冠肺炎患者和30例未服用L谷氨酰胺的患者进行研究。结果：新冠肺炎加L-谷氨酰胺组住院时间为10.4±1.9d，新冠肺炎加L-谷氨酰胺组为8.9d±1.8d(P=0.005)。新冠肺炎未加用L-谷氨酰胺组，有4例患者需要住ICU，而另一组无一例需要(p=0.038)。未服用L-谷氨酰胺的新冠肺炎组仅有1例死亡(p=0.999)。结论：L-谷氨酰胺等营养补充剂对免疫系统有促进作用，尤其是通过抑制炎症反应。我们的结果提示，新冠肺炎感染早期在正常营养中加入L-谷氨酰胺可能会缩短住院时间，减少对ICU的需要。在目前使用的治疗感染性疾病特别是新冠肺炎的基础上加用L-谷氨酰胺的效果还需要更大规模的研究来评估。
OBJECTIVES: The aim of this study is to investigate the effect of oral l-Glutamine supplementation on hospitalization time, need for intensive care unit and Coronavirus Disease-19 (Covid-19) mortality.METHODS: The study included 30 Covid-19 patients using l-Glutamine and 30 Covid-19 patients who did not use l-Glutamine with similar age, gender and clinical status. Diagnostic tests, laboratory examinations, clinical findings and computed thorax tomography imaging of the patients were evaluated.RESULTS: Hospitalization time was 10.4 ± 1.9 days in Covid-19 without L-Glutamine group and 8.9 ± 1.8 days in Covid-19 with L-Glutamine group (p = 0.005). In Covid-19 without the L-Glutamine group, four patients require the ICU though no one in the other group required that (p = 0.038). Only one mortality was observed in Covid-19 without the L-Glutamine group (p = 0.999).CONCLUSIONS: Nutritional supplements such as L-Glutamine boost immune system especially by inhibition of inflammatory responses. Our results suggest adding enteral L-glutamine to the normal nutrition in the early period of Covid-19 infection may lead to a shortened hospital stay and lead to less need for ICU. Larger-scale studies are needed to evaluate the effect of adding enteral L-Glutamine to the currently used treatments in the infectious diseases especially like Covid-19.