'Species' of peptidases
'Species' of peptidases
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DOI：
10.1515/bc.2007.151
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发表时间：
2007-11-01
影响因子：
3.7
通讯作者：
Rawlings, Neil D.
中科院分区：
文献类型：
--
作者：
Barrett, Alan J.;Rawlings, Neil D.
一个好的多肽酶命名和分类系统可以对这些酶的研究做出很大贡献。在已经描述了Merops系统中家族和宗族的构建之后，我们在这里重点介绍层次结构中的最低级别，在该级别中，大量的单个多肽酶蛋白被分配到我们所称的“物种”多肽酶中的较少数量。目前已知的肽长石种类刚刚超过2000种，但我们估计总有一天会有25000种。每个物种都是围绕着一种已被充分描述的肽酶蛋白构建的。然后，主要通过分析该家族的序列树来组装代表单个物种的多肽酶蛋白质簇。每种多肽酶都被赋予一个系统的识别符，并汇编一页关于它的数据摘要。由于新的多肽酶的特征远远落后于测序，大多数多肽酶蛋白到目前为止只被认为是氨基酸序列，还不能被归类为物种。我们认为，对未分配的肽酶序列的新形式的分析可能会给出它们将如何聚集到未来的新物种的早期迹象。
A good system for the naming and classification of peptidases can contribute much to the study of these enzymes. Having already described the building of families and clans in the MEROPS system, we here focus on the lowest level in the hierarchy, in which the huge number of individual pepticlase proteins are assigned to a lesser number of what we term 'species' of peptidases. Just over 2000 pepticlase species are recognised today, but we estimate that 25 000 will one day be known. Each species is built around a peptidase protein that has been adequately characterised. The cluster of peptidase proteins that represent the single species is then assembled primarily by analysis of a sequence 'tree' for the family. Each peptidase species is given a systematic identifier and a summary page of data regarding it is assembled. Because the characterisation of new peptidases lags far behind the sequencing, the majority of peptidase proteins are so far known only as amino acid sequences and cannot yet be assigned to species. We suggest that new forms of analysis of the sequences of the unassigned peptidases may give early indications of how they will cluster into the new species of the future.